PMID- 9794487
OWN - NLM
STAT- MEDLINE
DCOM- 19981106
LR  - 20061115
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 139
IP  - 11
DP  - 1998 Nov
TI  - Leptin decreases food intake induced by melanin-concentrating hormone (MCH), 
      galanin (GAL) and neuropeptide Y (NPY) in the rat.
PG  - 4739-42
AB  - Recent evidence suggests that leptin reduces food intake (FI) by acting at the 
      hypothalamic level. Leptin decreases hypothalamic neuropeptide Y (NPY), 
      melanin-concentrating hormone (MCH) and galanin (GAL) gene expression in rats. 
      The purpose of the present study was to test the hypothesis that leptin decreases 
      FI by additionally modulating the action of NPY, MCH or GAL in the hypothalamus. 
      Intracerebroventricular (i.c.v.) administration of NPY, MCH or GAL induced FI in 
      satiated rats. A prior i.c.v. injection of leptin (4 microg) completely prevented 
      the increase of FI either by MCH, GAL or NPY. These results suggest that 
      modulation of post-synaptic actions of MCH, GAL and NPY is one of the mechanisms 
      of leptin signaling in the hypothalamus.
FAU - Sahu, A
AU  - Sahu A
AD  - Department of Cell Biology and Physiology, University of Pittsburgh School of 
      Medicine, PA 15261, USA. asahu@vms.cis.pitt.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Appetite Stimulants)
RN  - 0 (Hypothalamic Hormones)
RN  - 0 (Leptin)
RN  - 0 (Melanins)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Pituitary Hormones)
RN  - 0 (Proteins)
RN  - 67382-96-1 (melanin-concentrating hormone)
RN  - 88813-36-9 (Galanin)
SB  - IM
MH  - Animals
MH  - Appetite Stimulants/*antagonists & inhibitors/*pharmacology
MH  - Eating/*drug effects
MH  - Galanin/*antagonists & inhibitors/*pharmacology
MH  - Hypothalamic Hormones/*antagonists & inhibitors/*pharmacology
MH  - Injections, Intraventricular
MH  - Leptin
MH  - Male
MH  - Melanins/*antagonists & inhibitors/*pharmacology
MH  - Neuropeptide Y/*antagonists & inhibitors/*pharmacology
MH  - Obesity/physiopathology
MH  - Pituitary Hormones/*antagonists & inhibitors/*pharmacology
MH  - Proteins/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1998/10/30 00:00
MHDA- 1998/10/30 00:01
CRDT- 1998/10/30 00:00
PHST- 1998/10/30 00:00 [pubmed]
PHST- 1998/10/30 00:01 [medline]
PHST- 1998/10/30 00:00 [entrez]
AID - 10.1210/endo.139.11.6432 [doi]
PST - ppublish
SO  - Endocrinology. 1998 Nov;139(11):4739-42. doi: 10.1210/endo.139.11.6432.