PMID- 9797082
OWN - NLM
STAT- MEDLINE
DCOM- 19981112
LR  - 20190921
IS  - 0939-5555 (Print)
IS  - 0939-5555 (Linking)
VI  - 77
IP  - 3
DP  - 1998 Sep
TI  - Low-molecular-weight heparin-induced skin necrosis.
PG  - 127-30
AB  - We report a case of low-molecular-weight heparin (LMWH)-induced skin necrosis in 
      a patient with chronic lymphatic leukemia. The patient had heparin-PF4 antibodies 
      and the heparin-induced platelet activation (HIPA) test was positive, but 
      platelet counts remained normal. Analysis of seven cases of LMWH-induced skin 
      necrosis revealed that this complication occurred mostly in patients previously 
      exposed to heparin, and that severe problems such as thrombocytopenia or 
      thromboembolic complications were rare. This is in contrast to skin necrosis 
      induced by unfractionated heparin (UFH), where a substantially higher number of 
      patients suffered from thrombocytopenia and thromboembolism. In addition, most 
      patients with UFH-induced skin necrosis were not pretreated with heparin. 
      Therefore, it is possible that LMWH is less immunogenic than UFH and requires 
      repeated exposure for induction of skin necrosis.
FAU - Fureder, W
AU  - Fureder W
AD  - Department of Internal Medicine I, AKH, University of Vienna, Austria.
FAU - Kyrle, P A
AU  - Kyrle PA
FAU - Gisslinger, H
AU  - Gisslinger H
FAU - Lechner, K
AU  - Lechner K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Fibrinolytic Agents/*adverse effects
MH  - Heparin, Low-Molecular-Weight/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Necrosis
MH  - Skin Diseases/*chemically induced/pathology
RF  - 28
EDAT- 1998/10/31 00:00
MHDA- 1998/10/31 00:01
CRDT- 1998/10/31 00:00
PHST- 1998/10/31 00:00 [pubmed]
PHST- 1998/10/31 00:01 [medline]
PHST- 1998/10/31 00:00 [entrez]
AID - 10.1007/s002770050427 [doi]
PST - ppublish
SO  - Ann Hematol. 1998 Sep;77(3):127-30. doi: 10.1007/s002770050427.