PMID- 9797774
OWN - NLM
STAT- MEDLINE
DCOM- 19981104
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 106
IP  - 2
DP  - 1998 Oct 15
TI  - Complex structural involvement of chromosome 7 in primary myelodysplastic 
      syndromes determined by fluorescence in situ hybridization.
PG  - 110-5
AB  - Cytogenetic analysis of 72 consecutive de novo myelodysplastic syndrome patients 
      revealed monosomy 7 in 12 cases. In 4 of these cases, the -7 was the only 
      abnormality, whereas the remaining 8 cases showed additional chromosomal 
      aberrations. Fluorescence in situ hybridization (FISH) utilizing chromosome 7 
      alpha-satellite and painting probes and other specific probes, when necessary, 
      provided evidence of unusual and unsuspected structural rearrangements involving 
      chromosome 7. FISH analysis showed that the small fragment found in one patient 
      and the ring found in each of two other patients were chromosome 7-derived rings. 
      FISH also revealed the insertion of chromosome 7 sequences into autosomes in 
      three other patients and unusual translocations in the remaining two patients. By 
      comparing the results obtained by using banding techniques to those obtained by 
      using the FISH technique, we deduced the involvement of chromosome 7 with partial 
      deletion of the short arm in all eight examined patients. Our study confirms the 
      ability of FISH to detect chromosomal aberrations that would otherwise not be 
      identified and the tendency of chromosome 7 to be involved in many different 
      rearrangements. From a clinical point of view, we confirm that patients affected 
      by myelodysplastic syndromes with complex karyotypes involving chromosome 7 do 
      not respond to treatment and have a poor prognosis.
FAU - Sessarego, M
AU  - Sessarego M
AD  - Department of Internal Medicine, University of Genoa, Genoa, Italy.
FAU - Fugazza, G
AU  - Fugazza G
FAU - Gobbi, M
AU  - Gobbi M
FAU - Bruzzone, R
AU  - Bruzzone R
FAU - Bisio, R
AU  - Bisio R
FAU - Ghio, R
AU  - Ghio R
FAU - Patrone, F
AU  - Patrone F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Anemia, Refractory, with Excess of Blasts/*genetics
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - *Chromosomes, Human, Pair 7
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Myelodysplastic Syndromes/*genetics
EDAT- 1998/11/03 00:00
MHDA- 1998/11/03 00:01
CRDT- 1998/11/03 00:00
PHST- 1998/11/03 00:00 [pubmed]
PHST- 1998/11/03 00:01 [medline]
PHST- 1998/11/03 00:00 [entrez]
AID - S0165460898000867 [pii]
AID - 10.1016/s0165-4608(98)00086-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1998 Oct 15;106(2):110-5. doi: 
      10.1016/s0165-4608(98)00086-7.