PMID- 9798673
OWN - NLM
STAT- MEDLINE
DCOM- 19981119
LR  - 20191102
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 17
IP  - 16
DP  - 1998 Oct 22
TI  - Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis.
PG  - 2019-25
AB  - Aberrations in Met-hepatocyte growth factor/scatter factor (HGF/SF) signaling 
      have been implicated in the acquisition of tumorigenic and metastatic phenotypes. 
      Here we show that murine NIH3T3 and C127 cells transformed by the Ras oncogene 
      overexpress the Met receptor, resulting in enhanced HGF/SF-mediated responses in 
      vitro including invasion through basement membrane. Accompanying the increase in 
      Met in ras-transformed NIH3T3 cells, there is a decrease in endogenous HGF/SF 
      expression as previously observed in cells exogenously overexpressing Met. 
      However, subcutaneously grown tumors and experimental lung metastases derived 
      from these cells express significantly higher levels of endogenous HGF/SF 
      together with high levels of Met. These results suggest Met-HGF/SF signaling 
      enhances tumor growth and metastasis of Ras-transformed NIH3T3 cells.
FAU - Webb, C P
AU  - Webb CP
AD  - ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, 
      Maryland 21702, USA.
FAU - Taylor, G A
AU  - Taylor GA
FAU - Jeffers, M
AU  - Jeffers M
FAU - Fiscella, M
AU  - Fiscella M
FAU - Oskarsson, M
AU  - Oskarsson M
FAU - Resau, J H
AU  - Resau JH
FAU - Vande Woude, G F
AU  - Vande Woude GF
LA  - eng
GR  - N01-CO-46000/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 3.6.5.2 (Oncogene Protein p21(ras))
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - Cell Line
MH  - Cell Line, Transformed
MH  - *Cell Transformation, Neoplastic
MH  - Dogs
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/secondary
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Nude
MH  - Oncogene Protein p21(ras)/genetics/*metabolism
MH  - Proto-Oncogene Proteins c-met/biosynthesis/*physiology
EDAT- 1998/11/03 00:00
MHDA- 1998/11/03 00:01
CRDT- 1998/11/03 00:00
PHST- 1998/11/03 00:00 [pubmed]
PHST- 1998/11/03 00:01 [medline]
PHST- 1998/11/03 00:00 [entrez]
AID - 10.1038/sj.onc.1202135 [doi]
PST - ppublish
SO  - Oncogene. 1998 Oct 22;17(16):2019-25. doi: 10.1038/sj.onc.1202135.