PMID- 9799971 OWN - NLM STAT- MEDLINE DCOM- 19990122 LR - 20111117 IS - 0192-415X (Print) IS - 0192-415X (Linking) VI - 26 IP - 2 DP - 1998 TI - HLA and HPA typing in idiopathic thrombocytopenic purpura patients treated with Kami-kihi-to. PG - 191-8 AB - We performed human leukocyte antigen (HLA) and human platelet antigen (HPA) in patients with Kami-kihi-to-responsive idiopathic thrombocytopenic purpura. The HLA-A2, A61 and Cw1 were significantly increased in responders compared with nonresponders, as were HLA DRB1 *0901, DRB1 *1502, and DPB1 *0501. In contrast, HLA DPB1 *0201 and DPB1 *0901 were significantly decreased in responders. The a/b genotype of HPA-2 and a/a genotype of HPA-3 were markedly increased in nonresponders, and anti-GPIb antibody was also increased. These results suggest that HLA, HPA, and anti-GP antibody studies may predict the response of idiopathic thrombocytopenic purpura to Kami-kihi-to. FAU - Matsuzaki, T AU - Matsuzaki T AD - Department of Blood Transfusion, Kansai Medical University, Osaka, Japan. FAU - Nomura, S AU - Nomura S FAU - Yamaoka, M AU - Yamaoka M FAU - Ozaki, Y AU - Ozaki Y FAU - Yoshimura, C AU - Yoshimura C FAU - Xie, G L AU - Xie GL FAU - Katsura, K AU - Katsura K FAU - Kagawa, H AU - Kagawa H FAU - Ishida, T AU - Ishida T FAU - Fukuhara, S AU - Fukuhara S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Singapore TA - Am J Chin Med JT - The American journal of Chinese medicine JID - 7901431 RN - 0 (Antigens, Human Platelet) RN - 0 (Drugs, Chinese Herbal) RN - 0 (HLA Antigens) RN - 0 (HLA-A2 Antigen) RN - 0 (HLA-B Antigens) RN - 0 (HLA-B61 antigen) RN - 0 (HLA-C Antigens) RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DRB1 Chains) SB - IM MH - Antigens, Human Platelet/*classification/genetics MH - Drugs, Chinese Herbal/*therapeutic use MH - Female MH - HLA Antigens/*classification/genetics MH - HLA-A2 Antigen/classification/genetics MH - HLA-B Antigens/classification/genetics MH - HLA-C Antigens/classification/genetics MH - HLA-DR Antigens/classification/genetics MH - HLA-DRB1 Chains MH - Histocompatibility Testing MH - Humans MH - Male MH - Purpura, Thrombocytopenic, Idiopathic/drug therapy/*immunology EDAT- 1998/11/04 00:00 MHDA- 1998/11/04 00:01 CRDT- 1998/11/04 00:00 PHST- 1998/11/04 00:00 [pubmed] PHST- 1998/11/04 00:01 [medline] PHST- 1998/11/04 00:00 [entrez] AID - S0192415X98000245 [pii] AID - 10.1142/S0192415X98000245 [doi] PST - ppublish SO - Am J Chin Med. 1998;26(2):191-8. doi: 10.1142/S0192415X98000245.