PMID- 9800281
OWN - NLM
STAT- MEDLINE
DCOM- 19990107
LR  - 20220318
IS  - 0039-128X (Print)
IS  - 0039-128X (Linking)
VI  - 63
IP  - 10
DP  - 1998 Oct
TI  - Placental 11 beta-hydroxysteroid dehydrogenase activity in normotensive and 
      pre-eclamptic pregnancies.
PG  - 511-5
AB  - Apparent mineralocorticoid excess and licorice induced hypertension, both 
      hypertensive disorders, have been attributed to a defect in the enzyme 11 
      beta-hydroxysteroid dehydrogenase (11 beta-HSD), which interconverts cortisol to 
      cortisone. Therefore, we undertook this study to determine the role of human 
      placental 11 beta-HSD activity in preeclampsia, which is a hypertensive disorder 
      in pregnancy. 11 beta-HSD activities were determined in placentas of 17 
      normotensive and 11 preeclamptic patients matched for gestational age at 34-42 
      weeks. Cortisol levels in umbilical venous and arterial sera were also determined 
      for both groups. Statistical analysis was performed using Student's t-test, 
      significance at p < 0.05. 11 beta-dehydrogenase (oxidation activity of 11 
      beta-HSD) activity was significantly lower in placentas of preeclamptic compared 
      to normotensive patients (0.19 +/- 0.09 vs. 0.26 +/- 0.08 mmoles/min/placenta, p 
      = 0.02). Cortisol level in umbilical cord blood was significantly higher in the 
      preeclamptic group (14.99 +/- 14.08 vs. 6.71 +/- 3.69 g/dL, p = 0.02). The 
      decreased 11 beta-HSD activity is accompanied by an expected increase in 
      umbilical cord blood cortisol level and decrease in fetal weight. This enzyme may 
      play an important role in influencing fetal growth.
FAU - McCalla, C O
AU  - McCalla CO
AD  - Department of Obstetrics and Gynecology, Health Science Center at Brooklyn, State 
      University of New York 11203, USA.
FAU - Nacharaju, V L
AU  - Nacharaju VL
FAU - Muneyyirci-Delale, O
AU  - Muneyyirci-Delale O
FAU - Glasgow, S
AU  - Glasgow S
FAU - Feldman, J G
AU  - Feldman JG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
RN  - 0U46U6E8UK (NAD)
RN  - 53-59-8 (NADP)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Female
MH  - Humans
MH  - Hydroxysteroid Dehydrogenases/*metabolism
MH  - NAD/metabolism
MH  - NADP/metabolism
MH  - Placenta/*enzymology
MH  - Pre-Eclampsia/*enzymology
MH  - Pregnancy/*metabolism
MH  - Pregnancy Trimester, Third
EDAT- 1998/11/04 00:00
MHDA- 1998/11/04 00:01
CRDT- 1998/11/04 00:00
PHST- 1998/11/04 00:00 [pubmed]
PHST- 1998/11/04 00:01 [medline]
PHST- 1998/11/04 00:00 [entrez]
AID - S0039-128X(98)00056-7 [pii]
AID - 10.1016/s0039-128x(98)00056-7 [doi]
PST - ppublish
SO  - Steroids. 1998 Oct;63(10):511-5. doi: 10.1016/s0039-128x(98)00056-7.