PMID- 9801028
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 99
IP  - 1
DP  - 1998 Sep 30
TI  - Analysis of environmental carcinogens associated with the incidence of lung 
      cancer.
PG  - 33-41
AB  - It is presumed that carcinogens present in human lungs contribute to the 
      incidence of lung cancer. Most of the carcinogens are inhaled in lung alveoli 
      with particulate matter through the respiratory tract. On the basis of chemical 
      analysis of 256 lung specimens with carcinomas resected in the period 1991 1996, 
      the concentration of 1-nitropyrene (1-NP) was 19.7+/-10.5 pg/g of dry weight, and 
      that of the dinitropyrenes (DNP) was 3.50+/-0.14-6.26+/-1.76. In addition, 
      2-nitrofluoranthene (NF) and 3-NF were detected at a higher level of 38.6+/-17.2 
      and 39.1+/-14.2, respectively, pg/g of dry weight. Concentrations of 
      benzo[a]pyrene, benzo[e]pyrene, benzo[k]fluoranthene and benzo[ghi]perylene in 37 
      specimens collected in the period 1991 1996, were in the range of 
      138+/-82-399+/-220 pg/g of dry weight. No difference was found in the 
      concentration of chemicals deposited in lung specimens from patients with lung 
      cancer and tuberculosis as a control. By following the prognosis of 112 patients 
      with carcinomas, we found that the deposition of 1-NP, 1,3-DNP, and 3-NF in lung 
      tissues influenced their 5-year-survival after determination of chemicals. Lung 
      specimens were divided into two groups of higher and lower chemical 
      concentrations at the levels of 18 pg/g for 1-NP, 15 for 1,3-DNP, and 35 for 
      3-NF, and the findings were statistically analyzed by adjusting for age, gender, 
      smoking status and cell type. The 5-year-survival of patients was markedly lower 
      in the higher concentration group than the lower group.
FAU - Tokiwa, H
AU  - Tokiwa H
AD  - Department of Environmental Health Science, Kyushu Women's University, 
      Kitakyushu, Japan. TOKIWA@cosmo.kwuc.ac.jp
FAU - Nakanishi, Y
AU  - Nakanishi Y
FAU - Sera, N
AU  - Sera N
FAU - Hara, N
AU  - Hara N
FAU - Inuzuka, S
AU  - Inuzuka S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Carcinogens, Environmental)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinogens, Environmental/adverse effects/*analysis
MH  - Environmental Pollutants/adverse effects/analysis
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lung/chemistry
MH  - Lung Neoplasms/chemically induced/*chemistry/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Mutagenicity Tests
MH  - Risk Factors
MH  - Salmonella/drug effects
MH  - Survival Rate
MH  - Tuberculosis/metabolism
EDAT- 1998/11/04 00:00
MHDA- 1998/11/04 00:01
CRDT- 1998/11/04 00:00
PHST- 1998/11/04 00:00 [pubmed]
PHST- 1998/11/04 00:01 [medline]
PHST- 1998/11/04 00:00 [entrez]
AID - S0378-4274(98)00136-2 [pii]
AID - 10.1016/s0378-4274(98)00136-2 [doi]
PST - ppublish
SO  - Toxicol Lett. 1998 Sep 30;99(1):33-41. doi: 10.1016/s0378-4274(98)00136-2.