PMID- 9802420
OWN - NLM
STAT- MEDLINE
DCOM- 19990119
LR  - 20190831
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 75-76
DP  - 1998 Sep 25
TI  - Antiepileptic effects of NPY on pentylenetetrazole seizures.
PG  - 279-82
AB  - Intracerebroventricular (i.c.v.) administration of NPY inhibits limbic seizure 
      activity induced by kainic acid or electrical hippocampal stimulation in vivo. 
      Similarly, antiepileptiform effects have been demonstrated in hippocampal slice 
      models. This suggests a possible antiepileptic potential of NPYergic agonists in 
      future treatment of complex partial seizures in humans. To further characterize 
      the antiepileptic potential of NPY, the effects of NPY administered i.c.v. were 
      studied on seizures induced by subcutaneous injection of pentylenetetrazole 
      (PTZ), a widely used antiepileptic screening test believed to model generalized 
      myoclonic seizures. NPY significantly and dose-dependently inhibited PTZ-induced 
      clonic seizures as revealed by increases in seizure latencies. In addition, NPY 
      caused an overall significant reduction in the number of rats developing tonic 
      seizures and in mortality following PTZ, indicating that NPY also reduces seizure 
      severity. By demonstrating antiepileptic activity of NPY in yet another seizure 
      model, this study further adds to the concept of NPY receptors as potentially 
      novel targets in future treatment of seizure disorders. Specifically, 
      antiepileptic effects in the PTZ model suggest that NPYergic agonists might also 
      prove active against human myoclonic seizures.
FAU - Woldbye, D P
AU  - Woldbye DP
AD  - Department of Pharmacology, University of Copenhagen, Copenhagen N, Denmark. 
      fidw@farmakol.ku.dk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Anticonvulsants)
RN  - 0 (Convulsants)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Receptors, Neuropeptide Y)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/administration & dosage/*pharmacology
MH  - Convulsants/toxicity
MH  - Disease Models, Animal
MH  - Humans
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuropeptide Y/administration & dosage/*pharmacology
MH  - Pentylenetetrazole/toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Neuropeptide Y/drug effects
MH  - Seizures/chemically induced/*prevention & control
EDAT- 1998/11/05 00:00
MHDA- 1998/11/05 00:01
CRDT- 1998/11/05 00:00
PHST- 1998/11/05 00:00 [pubmed]
PHST- 1998/11/05 00:01 [medline]
PHST- 1998/11/05 00:00 [entrez]
AID - S0167-0115(98)00079-2 [pii]
AID - 10.1016/s0167-0115(98)00079-2 [doi]
PST - ppublish
SO  - Regul Pept. 1998 Sep 25;75-76:279-82. doi: 10.1016/s0167-0115(98)00079-2.