PMID- 9802437
OWN - NLM
STAT- MEDLINE
DCOM- 19990119
LR  - 20190831
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 75-76
DP  - 1998 Sep 25
TI  - NPY-induced feeding involves the action of a Y1-like receptor in rodents.
PG  - 409-15
AB  - We have reported that the potent peptidic Y1 antagonist, 1229U91, significantly 
      suppressed NPY-induced and spontaneous feeding [32,33]. However, information on 
      the precise selectivity of 1229U91 for NPY receptors is lacking. The Y5 receptor 
      has been considered a key receptor for feeding regulation. In the present study 
      we showed that 1229U91 has high affinities for the human and rat Y1 receptors (Ki 
      = 0.041 nM and 0.16 nM, respectively) and also a high affinity for the human Y4 
      receptor (Ki = 0.33 nM), whereas it shows moderate affinities for the human Y2, 
      Y5 and rat Y5 receptors (K values of 20-170 nM). Moreover, 1229U91 potently 
      inhibits NPY-induced [Ca2+]i increases in cells expressing human Y1 receptors. In 
      contrast, 1229U91 is an agonist at other NPY receptors like the Y2, Y4 and Y5 
      receptors. Intracerebroventricular (i.c.v.)-injected 1229U91 (30 microg/head) 
      significantly suppressed human NPY-induced feeding in SD rats, while 1229U91 only 
      moderately inhibited bovine pancreatic polypeptide (bPP; an in vivo Y5 
      agonist)-induced feeding. These results indicate that the food intake evoked by 
      NPY might be mediated by the Y1 receptor, rather than the Y5 receptor. Thus, the 
      Y1 receptor or possibly a novel Y1-like receptor sensitive to 1229U91 may play a 
      key role in the regulation of NPY-induced feeding.
FAU - Kanatani, A
AU  - Kanatani A
AD  - Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Okubo, Japan. 
      kantniak@banyu.co.jp
FAU - Ito, J
AU  - Ito J
FAU - Ishihara, A
AU  - Ishihara A
FAU - Iwaasa, H
AU  - Iwaasa H
FAU - Fukuroda, T
AU  - Fukuroda T
FAU - Fukami, T
AU  - Fukami T
FAU - MacNeil, D J
AU  - MacNeil DJ
FAU - Van der Ploeg, L H
AU  - Van der Ploeg LH
FAU - Ihara, M
AU  - Ihara M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (1229U91)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Receptors, Neuropeptide Y)
RN  - 0 (neuropeptide Y-Y1 receptor)
RN  - 0 (neuropeptide Y5 receptor)
RN  - 59763-91-6 (Pancreatic Polypeptide)
SB  - IM
MH  - Animals
MH  - CHO Cells
MH  - COS Cells
MH  - Cattle
MH  - Cell Line
MH  - Cricetinae
MH  - Eating/*drug effects/*physiology
MH  - Humans
MH  - Injections, Intraventricular
MH  - Kinetics
MH  - Male
MH  - Neuropeptide Y/*pharmacology/physiology
MH  - Pancreatic Polypeptide/pharmacology
MH  - Peptides, Cyclic/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Neuropeptide Y/agonists/antagonists & inhibitors/*drug 
      effects/*physiology
EDAT- 1998/11/05 00:00
MHDA- 1998/11/05 00:01
CRDT- 1998/11/05 00:00
PHST- 1998/11/05 00:00 [pubmed]
PHST- 1998/11/05 00:01 [medline]
PHST- 1998/11/05 00:00 [entrez]
AID - S0167-0115(98)00096-2 [pii]
AID - 10.1016/s0167-0115(98)00096-2 [doi]
PST - ppublish
SO  - Regul Pept. 1998 Sep 25;75-76:409-15. doi: 10.1016/s0167-0115(98)00096-2.