PMID- 9802829
OWN - NLM
STAT- MEDLINE
DCOM- 19990301
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 61
IP  - 4
DP  - 1998 Dec
TI  - Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and 
      serotonin.
PG  - 361-6
AB  - The 3,4-methylenedioxymethamphetamine (MDMA)-induced increase in the 
      extracellular concentration of dopamine and the long-term depletion of 5-HT were 
      studied in the hippocampus of the rat brain. MDMA produced a dose-dependent 
      increase in the extracellular concentration of dopamine in the hippocampus, as 
      well as in the striatum. The MDMA-induced increase in the extracellular 
      concentration of dopamine in the hippocampus, but not in the striatum, was 
      suppressed in rats treated with the norepinephrine uptake inhibitor, desipramine, 
      and in rats in which noradrenergic neurons in the hippocampus were lesioned with 
      DSP4 (N-(2- chloroethyl)-N-ethyl-2-bromo benzylamine). However, the long-term 
      depletion of 5-HT in the hippocampus produced by MDMA was unaltered in 
      desipramine-treated rats. These results are supportive of the view that the 
      MDMA-induced increase in the extracellular concentration of dopamine in the 
      hippocampus is the result of an enhanced release of dopamine from noradrenergic 
      neurons. In addition, the MDMA-induced depletion of 5-HT in the hippocampus 
      appears not to involve dopamine-initiated processes, because suppression of 
      MDMA-induced dopamine release did not attenuate the long-term depletion of 5-HT 
      in the hippocampus.
FAU - Shankaran, M
AU  - Shankaran M
AD  - College of Pharmacy, University of Cincinnati, OH 45267-0004, USA.
FAU - Gudelsky, G A
AU  - Gudelsky GA
LA  - eng
GR  - DA07427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TG537D343B (Desipramine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/pharmacology
MH  - Animals
MH  - Desipramine/pharmacology
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
EDAT- 1998/11/05 00:00
MHDA- 1998/11/05 00:01
CRDT- 1998/11/05 00:00
PHST- 1998/11/05 00:00 [pubmed]
PHST- 1998/11/05 00:01 [medline]
PHST- 1998/11/05 00:00 [entrez]
AID - S0091-3057(98)00103-8 [pii]
AID - 10.1016/s0091-3057(98)00103-8 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1998 Dec;61(4):361-6. doi: 
      10.1016/s0091-3057(98)00103-8.