PMID- 9802842
OWN - NLM
STAT- MEDLINE
DCOM- 19990301
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 61
IP  - 4
DP  - 1998 Dec
TI  - Mechanism of action for reduction of ethanol intake in rats by the tachykinin 
      NK-3 receptor agonist aminosenktide.
PG  - 459-64
AB  - Intracerebroventricular (i.c.v.) injection of tachykinin (TK) NK-3 receptor 
      agonists inhibits alcohol intake in genetically selected alcohol-preferring rats. 
      The present study investigated the mechanism of action by which the selective TK 
      NK-3 receptor agonist aminosenktide (NH2-SENK) attenuates ethanol intake in 
      Marchigian Sardinian alcohol-preferring (msP) rats. The effect of NH2-SENK was 
      studied by i.c.v. injection in the conditioned taste aversion (CTA) and in the 
      conditioned place preference (CPP) paradigms; moreover, the effect of NH2-SENK on 
      blood alcohol levels (BAL) following intragastric ethanol administration was 
      investigated. The i.c.v. dose of 125 ng/rat of NH2-SENK, that markedly reduces 
      ethanol intake, did not modify BAL, nor did it increase the CTA induced by 
      intraperitoneal injection of ethanol, 1 g/kg body weight. These findings suggest 
      that the effect of NH2-SENK on alcohol consumption is not related to modification 
      of the pharmacokinetics of ethanol, nor to increase of the aversive properties of 
      ethanol. On the other hand, the same i.c.v. dose of NH2-SENK evoked a pronounced 
      and statistically significant CPP. This finding indicates that the TK NK-3 
      receptor agonist NH2-SENK possesses rewarding properties in msP rats and suggests 
      that its inhibitory effect on ethanol consumption may be due to substitution of 
      the rewarding properties of ethanol, thus making its consumption redundant.
FAU - Ciccocioppo, R
AU  - Ciccocioppo R
AD  - Department of Pharmacological Sciences and Experimental Medicine, University of 
      Camerino, Italy.
FAU - Panocka, I
AU  - Panocka I
FAU - Polidori, C
AU  - Polidori C
FAU - Froldi, R
AU  - Froldi R
FAU - Angeletti, S
AU  - Angeletti S
FAU - Massi, M
AU  - Massi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Neurokinin-3)
RN  - 104499-97-0 (substance P (5-11), Asp(5,6)-MePhe(8)-)
RN  - 33507-63-0 (Substance P)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - *Alcohol Drinking
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Choice Behavior
MH  - Ethanol/blood/*pharmacokinetics
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptide Fragments/*pharmacology
MH  - Rats
MH  - Receptors, Neurokinin-3/*agonists
MH  - Substance P/*analogs & derivatives/pharmacology
EDAT- 1998/11/05 00:00
MHDA- 1998/11/05 00:01
CRDT- 1998/11/05 00:00
PHST- 1998/11/05 00:00 [pubmed]
PHST- 1998/11/05 00:01 [medline]
PHST- 1998/11/05 00:00 [entrez]
AID - S0091-3057(98)00090-2 [pii]
AID - 10.1016/s0091-3057(98)00090-2 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1998 Dec;61(4):459-64. doi: 
      10.1016/s0091-3057(98)00090-2.