PMID- 9803012
OWN - NLM
STAT- MEDLINE
DCOM- 19981130
LR  - 20231221
IS  - 0065-1400 (Print)
IS  - 0065-1400 (Linking)
VI  - 58
IP  - 3
DP  - 1998
TI  - Activation of reward-relevant neurons in the caudate-putamen influences the 
      development of medial prefrontal cortex self-stimulation: a moveable electrode 
      mapping study.
PG  - 189-98
LID - 1273 [pii]
LID - 10.55782/ane-1998-1273 [doi]
AB  - Two hundred fifty five medial prefrontal cortical (MPFC) and 187 caudate-putamen 
      (CPu) sites were evaluated for intracranial self-stimulation in 67 animals using 
      moveable electrodes and collecting trade-off functions between current and 
      frequency. Eleven percent of the examined areas, located predominantly in the 
      ventromedial aspects of MPFC and CPu, showed reliable self-stimulation and the 
      average charge of 1.12 and 1.11 microC respectively, values that are in line with 
      those reported for the Medial forebrain bundle. The distribution of charge, 
      however, was greater than reported for the latter region, and ranged between 0.68 
      to 1.63 microC across sites. Some subjects were implanted with two electrodes, 
      one aimed at the MPFC, and the other at the CPu, ventral tegmental area, or 
      lateral hypothalamus. Only animals with CPu placements showed transference of 
      self-stimulation to the MPFC, suggesting that these two regions might form part 
      of the same reward substrate, a view that has anatomical, electrophysiological 
      and recently behavioral support.
FAU - Bielajew, C
AU  - Bielajew C
AD  - University of Ottawa, School of Psychology, Ontario, Canada.
FAU - Trzcinska, M
AU  - Trzcinska M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
SB  - IM
MH  - Animals
MH  - Caudate Nucleus/*cytology/*physiology
MH  - Male
MH  - Neurons/*physiology
MH  - Prefrontal Cortex/cytology/*physiology
MH  - Putamen/*cytology/*physiology
MH  - Rats
MH  - *Reward
MH  - Self Stimulation/*physiology
EDAT- 1998/11/06 00:00
MHDA- 1998/11/06 00:01
CRDT- 1998/11/06 00:00
PHST- 1998/11/06 00:00 [pubmed]
PHST- 1998/11/06 00:01 [medline]
PHST- 1998/11/06 00:00 [entrez]
AID - 1273 [pii]
AID - 10.55782/ane-1998-1273 [doi]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 1998;58(3):189-98. doi: 10.55782/ane-1998-1273.