PMID- 9804293
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 9
IP  - 13
DP  - 1998 Sep 14
TI  - Absence of thyroid hormone receptor beta-retinoid X receptor interactions in 
      auditory function and in the pituitary-thyroid axis.
PG  - 2933-7
AB  - THYROID hormone receptor beta-deficient (TRbeta-/-) mice have defective 
      auditory-evoked brain stem responses (ABR). Since in vitro, TRbeta binds to DNA 
      as homodimers or as heterodimers with retinoid X receptors (RXRs), we 
      investigated whether the TRbeta-/- phenotype may reflect loss of RXR-TRbeta 
      heterodimer or TRbeta homodimer function. Normal ABR thresholds were recorded in 
      RXRbeta-/-, RXRgamma-/-, RXRalpha-/+ and RXR compound mutant mice. When RXR 
      mutations were introduced onto TRbeta-/+ or TRbeta-/- backgrounds, thresholds 
      were dictated solely by TRbeta and not RXR genotype. TRbeta-/-mice also 
      over-produce thyroid hormones and thyroid stimulating hormone; however, levels of 
      these hormones were unaltered by RXR mutations. This suggests that, contrary to 
      in vitro models, RXRs may be dispensable and that TRbeta may function in vivo by 
      an RXR-independent mechanism in the auditory system and pituitary-thyroid axis.
FAU - Barros, A C
AU  - Barros AC
AD  - Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, 
      USA.
FAU - Erway, L C
AU  - Erway LC
FAU - Krezel, W
AU  - Krezel W
FAU - Curran, T
AU  - Curran T
FAU - Kastner, P
AU  - Kastner P
FAU - Chambon, P
AU  - Chambon P
FAU - Forrest, D
AU  - Forrest D
LA  - eng
GR  - DC 03441-01/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Auditory Threshold/physiology
MH  - Brain Stem/physiology
MH  - DNA-Binding Proteins
MH  - Evoked Potentials, Auditory/physiology
MH  - Gene Deletion
MH  - Hearing/*physiology
MH  - Heterozygote
MH  - Homozygote
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Nuclear Proteins
MH  - Pituitary Gland/*physiology
MH  - Receptors, Retinoic Acid/*metabolism
MH  - Receptors, Thyroid Hormone/*metabolism
MH  - Retinoid X Receptors
MH  - Thyroid Gland/*physiology
MH  - Transcription Factors/*metabolism
EDAT- 1998/11/06 00:00
MHDA- 1998/11/06 00:01
CRDT- 1998/11/06 00:00
PHST- 1998/11/06 00:00 [pubmed]
PHST- 1998/11/06 00:01 [medline]
PHST- 1998/11/06 00:00 [entrez]
AID - 10.1097/00001756-199809140-00003 [doi]
PST - ppublish
SO  - Neuroreport. 1998 Sep 14;9(13):2933-7. doi: 10.1097/00001756-199809140-00003.