PMID- 9804296
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 9
IP  - 13
DP  - 1998 Sep 14
TI  - Parkinson's disease selectively impairs preattentive auditory processing: an MEG 
      study.
PG  - 2949-52
AB  - Auditory stimuli elicit auditory evoked magnetic fields (AEFs) called P50m and 
      N100m, which index preconscious auditory processing in human. We investigated 
      with a whole-head magnetometer whether Parkinson's disease (PD) impairs parallel 
      preattentive auditory processing between the hemispheres. Stimulus blocks 
      consisting of standard (80%) and deviant (20%) tones were monaurally presented in 
      a passive condition to 11 PD patients with unilateral motor symptoms and to 11 
      age-matched healthy controls. The constant interstimulus intervals (ISIs) were 
      0.5 s and 2.5 s in separate blocks. The interhemispheric latency differences of 
      the P50m and N100m were significantly lengthened in PD patients in the left-ear 
      condition. This might be caused by the basal ganglia dysfunction in PD together 
      with the simultaneous age-related neural degeneration predominant in the left 
      auditory cortex.
FAU - Pekkonen, E
AU  - Pekkonen E
AD  - Department of Neurology, University of Helsinki, Finland.
FAU - Ahveninen, J
AU  - Ahveninen J
FAU - Virtanen, J
AU  - Virtanen J
FAU - Teravainen, H
AU  - Teravainen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
SB  - IM
MH  - Acoustic Stimulation
MH  - Analysis of Variance
MH  - Auditory Pathways/physiology
MH  - Auditory Perception/*physiology
MH  - Electrooculography
MH  - Evoked Potentials, Auditory/physiology
MH  - Functional Laterality
MH  - Humans
MH  - *Magnetoencephalography
MH  - Middle Aged
MH  - Parkinson Disease/*physiopathology
MH  - Time Factors
EDAT- 1998/11/06 00:00
MHDA- 1998/11/06 00:01
CRDT- 1998/11/06 00:00
PHST- 1998/11/06 00:00 [pubmed]
PHST- 1998/11/06 00:01 [medline]
PHST- 1998/11/06 00:00 [entrez]
AID - 10.1097/00001756-199809140-00006 [doi]
PST - ppublish
SO  - Neuroreport. 1998 Sep 14;9(13):2949-52. doi: 10.1097/00001756-199809140-00006.