PMID- 9805235
OWN - NLM
STAT- MEDLINE
DCOM- 19990112
LR  - 20181201
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 20
IP  - 4
DP  - 1998 Nov
TI  - Inhibitory effect of anaphylactic reaction of Sosiho-Tang.
PG  - 567-78
AB  - Mast cells synthesize and secrete chemical mediators which play an central role 
      in anaphylactic reactions. Compound 48/80 is a condensation product of 
      formaldehyde with paramethoxyphenylethylamine that reliably induces the release 
      of chemical mediators in the mast cell granules. Aggregation of the high-affinity 
      Fc receptor also stimulates the mast cells. The objective of the current study 
      was to determine the effect of Sosiho-Tang (SS-Tang) on mast cell-mediated 
      anaphylactic reaction. SS-Tang completely inhibited systemic anaphylaxis induced 
      by compound 48/80 in mice. SS-Tang inhibited local anaphylaxis induced by 
      anti-dinitrophenyl (DNP) IgE. In addition SS-Tang concentration-dependently 
      inhibited histamine release in mast cells induced by compound 48/80 or anti-DNP 
      IgE. These results indicate that SS-Tang may contain compounds with actions that 
      inhibit mast cell degranulation.
FAU - Kim, H M
AU  - Kim HM
AD  - College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
FAU - Kim, Y Y
AU  - Kim YY
FAU - Moon, H S
AU  - Moon HS
FAU - Lee, E H
AU  - Lee EH
FAU - Moon, S J
AU  - Moon SJ
FAU - An, N H
AU  - An NH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Animals
MH  - Dinitrobenzenes/immunology
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Mast Cells/drug effects/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis/*drug effects/immunology
MH  - Rats
MH  - Rats, Wistar
MH  - p-Methoxy-N-methylphenethylamine/immunology/toxicity
EDAT- 1998/11/07 00:00
MHDA- 1998/11/07 00:01
CRDT- 1998/11/07 00:00
PHST- 1998/11/07 00:00 [pubmed]
PHST- 1998/11/07 00:01 [medline]
PHST- 1998/11/07 00:00 [entrez]
AID - 10.3109/08923979809031517 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 1998 Nov;20(4):567-78. doi: 
      10.3109/08923979809031517.