PMID- 9806291
OWN - NLM
STAT- MEDLINE
DCOM- 19990121
LR  - 20190512
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 13
IP  - 9
DP  - 1998 Sep
TI  - Effects of interferon-gamma on cytokine production by endometrial stromal cells.
PG  - 2598-601
AB  - To clarify the role of interferon-gamma (IFN-gamma) in reproduction, we have 
      examined its effects on cytokine production by human endometrial stromal cells 
      (ESC). Concentrations of interleukin (IL)-6, IL-8, monocyte chemoattractant 
      protein-1 (MCP-1), and macrophage colony-stimulating factor (M-CSF) in the 
      culture media of normal ESC and an endometrial stromal sarcoma cell line, MaMi, 
      were measured using an enzyme-linked immunosorbent assay. Both non-stimulated ESC 
      and non-stimulated MaMi cells constitutively secrete IL-6, IL-8, MCP-1, and 
      M-CSF. In a dose-dependent manner, IFN-gamma increased the concentrations of 
      IL-6, MCP-1, and M-CSF and reduced the concentrations of IL-8 in ESC and MaMi 
      cells. These results suggest that IFN-gamma produced by both decidual 
      inflammatory cells and the developing embryo plays a role in the maintenance of 
      early pregnancy by modulating the production of these cytokines by human ESC.
FAU - Nasu, K
AU  - Nasu K
AD  - Department of Obstetrics and Gynecology, Oita Medical University, Japan.
FAU - Matsui, N
AU  - Matsui N
FAU - Narahara, H
AU  - Narahara H
FAU - Tanaka, Y
AU  - Tanaka Y
FAU - Miyakawa, I
AU  - Miyakawa I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Cells, Cultured
MH  - Chemokine CCL2/biosynthesis
MH  - Cytokines/*biosynthesis
MH  - Endometrium/*cytology/*metabolism
MH  - Female
MH  - Humans
MH  - Interferon-gamma/*pharmacology
MH  - Interleukin-6/biosynthesis
MH  - Interleukin-8/biosynthesis
MH  - Macrophage Colony-Stimulating Factor/biosynthesis
MH  - Pregnancy
MH  - Stromal Cells/cytology/*metabolism
EDAT- 1998/11/07 00:00
MHDA- 1998/11/07 00:01
CRDT- 1998/11/07 00:00
PHST- 1998/11/07 00:00 [pubmed]
PHST- 1998/11/07 00:01 [medline]
PHST- 1998/11/07 00:00 [entrez]
AID - 10.1093/humrep/13.9.2598 [doi]
PST - ppublish
SO  - Hum Reprod. 1998 Sep;13(9):2598-601. doi: 10.1093/humrep/13.9.2598.