PMID- 9806442
OWN - NLM
STAT- MEDLINE
DCOM- 19990129
LR  - 20190826
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 95
IP  - 2
DP  - 1998 Oct
TI  - Effects of serotonergic drugs on lateralized aggression and aggressive displays 
      in Anolis carolinensis.
PG  - 227-32
AB  - Previous work demonstrated that the brains of many reptiles, including the 
      American chameleon Anolis carolinensis (A. carolinensis), are functionally 
      'split'. Because the left eye in this species projects predominantly to the right 
      hemisphere, and vice versa, inferences about lateralized brain functioning can be 
      made in A. carolinensis by observation of eye use during behavioral encounters. 
      Using this model, past work suggested that territorial aggression in Anolis is 
      under the preferential control of the right hemisphere, and that acute stress or 
      chronic alcohol exposure selectively reduces right hemisphere mediated 
      territorial aggression. In addition, drugs which increase serotonin (5-HT) in the 
      synaptic cleft inhibit aggressive responding in anoles in both hemispheres. The 
      current experiment examined whether or not the administration of the serotonin 
      agonists 8-hydroxy-2-(di-n-propylamine) tetralin (8-OHDPAT), quipazine, or 
      meta-chlorophenylbiguanide (mCPBG) alter territorial aggression in Anolis. Nine 
      adult socially isolated male A. carolinensis underwent a series of behavioral 
      trials during which an antagonistic male was introduced into the cage. Once 
      stable responding was initiated, all subjects were injected in a semi-randomized 
      crossover manner with the following agents, (1) lactated Ringer's, (2) the 5-HT2 
      agonist quipazine (1.5 mg/kg and 3.0 mg/kg), (3) the 5-HT1 agonist 8-OHDPAT (83 
      mg/kg), and (4) the 5-HT3 agonist mCPBG (3.0 mg/kg and 9 mg/kg). Twenty minutes 
      post injections, the male intruder was reintroduced into the subject's cage. 
      Several behaviors were recorded, including: (1) the time to the first aggressive 
      response, (2) the number of aggressive episodes mediated by the left eye or right 
      eye, and (3) changes in skin color and posture. Aggressive responding was 
      virtually eliminated in all subjects injected with 8-OHDPAT. On the other hand, 
      one-way ANOVA found that both the 9 mg/kg dose of mCPBG (P=0.007), and the 3.0 
      mg/kg dose of quipazine (P=0.035), selectively decreased territorial aggression 
      mediated by the left eye/right hemisphere compared to lactated Ringer's controls, 
      but had no effect on aggression mediated by the right eye/left hemisphere. 
      Although 8-OHDPAT inhibited aggression, injected subjects developed phenotypic 
      displays of aggressive coloring/posturing, such as blackening of the eye spot and 
      a raising of the neck crest. These results suggest that aggressive action can be 
      differentiated from phenotypic displays that accompany aggression by a 5-HT1 
      agonist. They also indicate that there is an asymmetrical effect of 5-HT2/5-HT3 
      serotonin agonists on hemispheric mediation of aggression in this species.
FAU - Deckel, A W
AU  - Deckel AW
AD  - University of Connecticut Health Center, Farmington 06030-2130, USA. 
      AwallaceD@msn.com
FAU - Fuqua, L
AU  - Fuqua L
LA  - eng
GR  - P50-AA3510/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Biguanides)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Receptors, Serotonin, 5-HT3)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 4WCY05C0SJ (Quipazine)
RN  - 5304-59-6 (4-chlorophenylbiguanide)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Aggression/*drug effects
MH  - Animals
MH  - Biguanides/pharmacology
MH  - Functional Laterality/*drug effects
MH  - Lizards/*physiology
MH  - Male
MH  - Posture
MH  - Quipazine/pharmacology
MH  - Receptors, Serotonin/drug effects
MH  - Receptors, Serotonin, 5-HT3
MH  - Serotonin Receptor Agonists/*pharmacology
EDAT- 1998/11/07 00:00
MHDA- 1998/11/07 00:01
CRDT- 1998/11/07 00:00
PHST- 1998/11/07 00:00 [pubmed]
PHST- 1998/11/07 00:01 [medline]
PHST- 1998/11/07 00:00 [entrez]
AID - S0166432898000485 [pii]
AID - 10.1016/s0166-4328(98)00048-5 [doi]
PST - ppublish
SO  - Behav Brain Res. 1998 Oct;95(2):227-32. doi: 10.1016/s0166-4328(98)00048-5.