PMID- 9809027
OWN - NLM
STAT- MEDLINE
DCOM- 19981113
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 107
IP  - 1
DP  - 1998 Nov
TI  - Aberrations of chromosomes 1 and 17 in six human osteosarcoma cell lines using 
      double-target fluorescence in situ hybridization.
PG  - 7-10
AB  - Analysis of six human osteosarcoma cell lines was performed by using 
      double-target fluorescence in situ hybridization (FISH). FISH was applied to 
      interphase nuclei, not to metaphase chromosomes. In this study, numerical 
      aberrations of chromosomes 1 and 17 or structural chromosomal aberrations of 
      chromosome arm 1p or 17p, in which it has been suggested that there are one or 
      more tumor suppressor genes in various malignant tumors, were examined with this 
      technique. All six of the human osteosarcoma cell lines studied had extra copies 
      of chromosomes 1 and 17. A high frequency of deletions (> 60%) in chromosome 1 
      was found in two cell lines and deletions of chromosome 17 were found in one cell 
      line.
FAU - Murata, H
AU  - Murata H
AD  - Department of Orthopaedics, Kyoto Prefectural University of Medicine, Japan.
FAU - Kusuzaki, K
AU  - Kusuzaki K
FAU - Takeshita, H
AU  - Takeshita H
FAU - Hirasawa, Y
AU  - Hirasawa Y
FAU - Ashihara, T
AU  - Ashihara T
FAU - Abe, T
AU  - Abe T
FAU - Inazawa, J
AU  - Inazawa J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Bone Neoplasms/*genetics
MH  - Chromosome Aberrations/*genetics
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Osteosarcoma/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1998/11/11 00:00
MHDA- 1998/11/11 00:01
CRDT- 1998/11/11 00:00
PHST- 1998/11/11 00:00 [pubmed]
PHST- 1998/11/11 00:01 [medline]
PHST- 1998/11/11 00:00 [entrez]
AID - S0165460898000727 [pii]
AID - 10.1016/s0165-4608(98)00072-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1998 Nov;107(1):7-10. doi: 10.1016/s0165-4608(98)00072-7.