PMID- 9809036
OWN - NLM
STAT- MEDLINE
DCOM- 19981113
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 107
IP  - 1
DP  - 1998 Nov
TI  - Analysis of MYC and chromosome 8 copy number changes in gastrointestinal cancers 
      by dual-color fluorescence in situ hybridization.
PG  - 61-4
AB  - We performed dual (two-color) fluorescence in situ hybridization (FISH) by using 
      direct fluorescent labeling probes for C-MYC and chromosome 8 in six 
      gastrointestinal (three stomach and three colon) cancers. There are several 
      reports of increased C-MYC copy numbers in solid tumors. To date, however, 
      genetic rearrangements including those of the C-MYC gene have not actually been 
      detected by FISH. Metaphase FISH demonstrated the C-MYC gene on other chromosomes 
      (i.e., in addition to chromosome 8) in one gastric cancer. Somatic mutations such 
      as chromosome translocation or insertion including the C-MYC gene are assumed to 
      have occurred in this case. Our results suggest that genetic rearrangements, in 
      addition to an increased C-MYC copy number, may be a mechanism of MYC oncogene 
      activation in solid tumors.
FAU - Takahashi, Y
AU  - Takahashi Y
AD  - Department of Pharmacology, Nihon University School of Medicine, Tokyo, Japan.
FAU - Shintaku, K
AU  - Shintaku K
FAU - Ishii, Y
AU  - Ishii Y
FAU - Asai, S
AU  - Asai S
FAU - Ishikawa, K
AU  - Ishikawa K
FAU - Fujii, M
AU  - Fujii M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adenocarcinoma/*genetics
MH  - Adenocarcinoma, Mucinous/genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Colonic Neoplasms/*genetics
MH  - Genes, myc/*genetics
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Stomach Neoplasms/*genetics
EDAT- 1998/11/11 00:00
MHDA- 1998/11/11 00:01
CRDT- 1998/11/11 00:00
PHST- 1998/11/11 00:00 [pubmed]
PHST- 1998/11/11 00:01 [medline]
PHST- 1998/11/11 00:00 [entrez]
AID - S0165460898000892 [pii]
AID - 10.1016/s0165-4608(98)00089-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1998 Nov;107(1):61-4. doi: 10.1016/s0165-4608(98)00089-2.