PMID- 9809754
OWN - NLM
STAT- MEDLINE
DCOM- 19981123
LR  - 20220311
IS  - 0002-8614 (Print)
IS  - 0002-8614 (Linking)
VI  - 46
IP  - 11
DP  - 1998 Nov
TI  - Congestive heart failure and cognitive impairment in an older population. 
      Osservatorio Geriatrico Campano Study Group.
PG  - 1343-8
AB  - OBJECTIVE: Congestive heart failure (CHF) is potentially preventable, and the 
      identification of modifiable risk factors for cognitive impairment (CI) for older 
      persons is a very important issue. We examined the cross-sectional relationship 
      between CHF and CI in an older population. DESIGN: A cross-sectional survey. 
      SETTING AND PARTICIPANTS: A total of 1339 subjects aged 65 and older were 
      selected from the electoral rolls of Campania, a region of southern Italy. 
      MEASUREMENTS: Sociodemographic characteristics were recorded, as was the presence 
      of cardiovascular diseases, including CHF classified according to the New York 
      Heart Association (NYHA) guidelines for disease severity; CI evaluated by means 
      of the Mini-Mental State Examination (MMSE), with a score of <24 indicating 
      impairment; geriatric depression scale (GDS) rating; blood pressure (BP); and 
      heart rate (HR). RESULTS: The final sample numbered 1075; 172 subjects were 
      excluded because of neurological disorders and psychotropic therapy, and 92 were 
      excluded because their BP, HR, or cognitive examination was not recorded. 
      Prevalence of CHF was 8.2%, and 23.0% of subjects scored <24 on the MMSE. The 
      prevalence of CHF in subjects with an MMSE score of <24 and > or =24 was 20.2% 
      and 4.6%, respectively (P < .001). Logistic regression analysis showed that CHF 
      was associated independently with CI by sex, age, educational level, GDS, 
      diabetes, hypertension, alcohol consumption, smoking, atrial fibrillation, 
      systolic and diastolic BP, and HR. The risk of CI was 1.96-fold greater in 
      subjects with CHF (odds ratio: 1.96; 95% confidence interval: 1.07-3.58; P < 
      .028). Systolic BP decrease was correlated negatively with NYHA classes only in 
      subjects with CI (r = -0.981; P < .020), whereas HR increase was correlated 
      positively with NYHA classes only in subjects without CI (r = 0.985; P < .015). 
      CONCLUSIONS: In our population, CHF is associated with CI in subjects aged 65 
      years and older. Systolic BP reduction and the lack of HR increase, related to 
      NYHA classes, might characterize cognitively impaired subjects with CHF.
FAU - Cacciatore, F
AU  - Cacciatore F
AD  - Cattedra di Geriatria, Istituto di Medicina Interna, Cardiologia e Chirurgia 
      Cardiovascolare, Universita degli Studi di Napoli Federico II, Naples, Italy.
FAU - Abete, P
AU  - Abete P
FAU - Ferrara, N
AU  - Ferrara N
FAU - Calabrese, C
AU  - Calabrese C
FAU - Napoli, C
AU  - Napoli C
FAU - Maggi, S
AU  - Maggi S
FAU - Varricchio, M
AU  - Varricchio M
FAU - Rengo, F
AU  - Rengo F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Aged
MH  - Cognition Disorders/diagnosis/epidemiology/*etiology
MH  - Cross-Sectional Studies
MH  - Educational Status
MH  - Female
MH  - Geriatric Assessment
MH  - Heart Failure/classification/*complications/epidemiology
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Mental Status Schedule
MH  - Prevalence
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Socioeconomic Factors
EDAT- 1998/11/11 00:00
MHDA- 1998/11/11 00:01
CRDT- 1998/11/11 00:00
PHST- 1998/11/11 00:00 [pubmed]
PHST- 1998/11/11 00:01 [medline]
PHST- 1998/11/11 00:00 [entrez]
AID - 10.1111/j.1532-5415.1998.tb05999.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 1998 Nov;46(11):1343-8. doi: 
      10.1111/j.1532-5415.1998.tb05999.x.