PMID- 9809862
OWN - NLM
STAT- MEDLINE
DCOM- 19981231
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 358
IP  - 1
DP  - 1998 Sep 25
TI  - Effect of once weekly treatment with 3,4-methylenedioxymethamphetamine on 
      schedule-controlled behavior in rats.
PG  - 1-8
AB  - The present study examined the effects of 3,4-methylenedioxymethamphetamine 
      (MDMA), before and after once a week dosing, on the behavior of rats responding 
      under a fixed ratio 20 schedule of reinforcement. Acutely, cumulative doses of 
      MDMA dose-dependently decreased responding when compared to a series of water 
      injections. Rats were then separated into two groups, one of which received only 
      weekly MDMA ('paired') while the other received an additional injection of water 
      each week ('unpaired'). Weekly dosing with MDMA resulted in significantly 
      increased responding at low doses in the paired group but not in the unpaired 
      group. When water injections were readministered there was a significant increase 
      in responding in both groups. During the weekly regimen, locomotor activity also 
      increased significantly over time after both water and MDMA injections. In 
      conclusion, it appears that even weekly dosing with a small amount of MDMA can 
      have long-lasting effects that are manifested in both operant and spontaneous 
      behavior and that may be mediated by a conditioning mechanism.
FAU - Nagilla, R
AU  - Nagilla R
AD  - Department of Pharmacal Sciences, Auburn University, AL 36849, USA.
FAU - Newland, M C
AU  - Newland MC
FAU - Snyder, J
AU  - Snyder J
FAU - Bronson, M E
AU  - Bronson ME
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Hallucinogens)
RN  - 059QF0KO0R (Water)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Conditioning, Operant/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reinforcement Schedule
MH  - Water/administration & dosage
EDAT- 1998/11/11 00:00
MHDA- 1998/11/11 00:01
CRDT- 1998/11/11 00:00
PHST- 1998/11/11 00:00 [pubmed]
PHST- 1998/11/11 00:01 [medline]
PHST- 1998/11/11 00:00 [entrez]
AID - S0014-2999(98)00569-X [pii]
AID - 10.1016/s0014-2999(98)00569-x [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1998 Sep 25;358(1):1-8. doi: 10.1016/s0014-2999(98)00569-x.