PMID- 9812809
OWN - NLM
STAT- MEDLINE
DCOM- 19981216
LR  - 20161124
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 49
IP  - 3
DP  - 1997 Jun
TI  - [Norepinephrine regulation of T-lymphocyte proliferation of rat during acute 
      hypoxia].
PG  - 261-6
AB  - Interaction between the immune and neuroendocrine systems has long been noted. In 
      the present study, the role of norepinephrine (NE) in immunoregulation of rats 
      during simulated hypoxia in hypobaric chamber was examined. It was found that 7 
      km for 24 h of hypoxia inhibited T-lymphocyte proliferation by 41%. 7 d and 20 d 
      of hypoxia, simulating 5 km altitude, reduces T-lymphocyte proliferation 
      respectively 34% and 60%. Intracerebroventricular (i.c.v.) injection of 5 x 
      10(-6) mol/L NE decreased T-lymphocyte proliferation by 29%. I.c.v. injection of 
      phentolamine 25 micrograms/rat prior to 7 km for 10 h hypoxia attenuated the 
      hypoxia-induced suppression of T-lymphocyte proliferation from 42% to 21%. In 
      additon, 7 km 10 h hypoxia increased CRF levels in blood and catecholamines in 
      hypothalamus. An increased circulation CRF level was also noted after NE 
      injection (i.c.v.) of 5 x 10(-6) mol/L. Hypoxia corresponding 7 km altitude for 
      10 h stimulates spleen-lymphocytes incubated with CRF, but T-lymphocyte 
      proliferation decreclsed with increasing CRF concentration. These findings 
      suggest that hypoxia inhibits T-lymphocyte proliferation probably through an 
      immune inhibition action by CRF-NE.
FAU - Bai, H B
AU  - Bai HB
AD  - Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining.
FAU - Du, J Z
AU  - Du JZ
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Corticotropin-Releasing Hormone/*blood
MH  - Hypoxia/*immunology
MH  - *Lymphocyte Activation
MH  - Male
MH  - Norepinephrine/pharmacology/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1997/06/01 00:00
MHDA- 1998/11/13 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1998/11/13 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 1997 Jun;49(3):261-6.