PMID- 9812820
OWN - NLM
STAT- MEDLINE
DCOM- 19981216
LR  - 20231213
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 49
IP  - 3
DP  - 1997 Jun
TI  - [Antagonistic effect of orphanin FQ on morphine analgesia in rat brain].
PG  - 333-8
AB  - The discovery of a novel receptor-opioid receptor-like (ORL) receptor (1994) and 
      its endogenous ligand-Orphanin FQ (OFQ) (1995) represented a new approach in the 
      study of opioids and anti-opioids in CNS. Based on the high homology of ORL 
      receptor and OFQ with their opioid family counterparts, as well as the high 
      expression of ORL receptor mRNA and protein in the brain areas associated with 
      nociception, the effect of OFQ on morphine induced analgesia in the rat brain was 
      further investigated. The results showed that: (1) Intracerebroventricular 
      (i.c.v.) injection of OFQ reversed the stress analgesia induced by i.c.v. 
      injection of normal saline, which seems to be mediated by endogenous opioid 
      peptides. (2) I.c.v. injection of OFQ dose-dependently antagonized 
      morphine-induced analgesia dose-dependently. (3) I.c.v. injection of antisense 
      oligodeoxynucleotide for the gene encoding ORL receptor to block the expression 
      of ORL receptor in the CNS potentiated the analgesia induced by cumulative 
      injection of morphine. The results suggest that OFQ seems to play a role of 
      anti-opioid peptide in the rat brain.
FAU - Tian, J H
AU  - Tian JH
AD  - Neuroscience Research Center, Beijing Medical University.
FAU - Xu, W
AU  - Xu W
FAU - Fang, Y
AU  - Fang Y
FAU - Han, J S
AU  - Han JS
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Opioid Peptides)
RN  - 0 (Receptors, Opioid)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Analgesics, Opioid/*pharmacology
MH  - Animals
MH  - Brain/metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Morphine/*pharmacology
MH  - Oligonucleotides, Antisense
MH  - Opioid Peptides/*pharmacology/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Opioid/*agonists
MH  - Nociceptin
EDAT- 1997/06/01 00:00
MHDA- 1998/11/13 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1998/11/13 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 1997 Jun;49(3):333-8.