PMID- 9812852
OWN - NLM
STAT- MEDLINE
DCOM- 19990105
LR  - 20161124
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 49
IP  - 2
DP  - 1997 Apr
TI  - [Inhibition effect of hypoxia on humoral immunity of rats].
PG  - 167-72
AB  - To study the effect of hypoxia on humoral immunity function of rat and Ochotona 
      curzoniae (pika), the specific antibody production to novel antigen IgG and 
      immunoresponse to sheep red blood cell (hemolysin forming) were measured. The 
      results show that hypoxia at altitude of 5 km and 7 km for 10 d resulted 
      respectively in 10.3% (P < 0.05) and 21.9% (P < 0.05) decrement in hemolysin 
      formation in rats, as compared with the control group kept at 2.3 km. When the 
      rats were secondarily immunized and kept at the same hypoxia for 10 d, the 
      reduction in hemolysin formation was 4.2% (P < 0.05) and 4.6% (P < 0.05) for the 
      two respective altitudes. These changes, however, were not found in pikas. When 
      rats were immunized two days before hypoxia, 5 km hypoxia for 5 d and 8 d failed 
      to suppress hemolysin formation. Intracerebroventricular (i.c.v.) injection of 
      CRF (1.0 microgram/rat), decreased hemolysin formation and production of IgG by 
      8.6% (P < 0.05) and 14.0% (P < 0.05) respectively, but intraperitoneal (i.p.) 
      injection of CRF (1.0 microgram/rat) had no effect. On the other hand, i.c.v. 
      injection of CRF receptor antagonist (alpha-helical CRF (9-41), 50 
      micrograms/rat) prior to 7 km hypoxia caused a hypoxia-induced suppression of IgG 
      production from 24.2% to 12.1% (P < 0.05). Adrenalectomy in rats lowered 
      hemolysin formation by 6.6% (P < 0.05). The above results demonstrate that 
      hypoxia suppresses humoral immunity function and alters initial antigen 
      processing probably through an increase of CRF in the central nervous system.
FAU - Bai, H B
AU  - Bai HB
AD  - Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining.
FAU - Du, J Z
AU  - Du JZ
FAU - Jia, H W
AU  - Jia HW
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Hemolysin Proteins)
RN  - 0 (Immunoglobulin G)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Altitude
MH  - Animals
MH  - Corticotropin-Releasing Hormone/physiology
MH  - Female
MH  - Hemolysin Proteins/*biosynthesis
MH  - Hypoxia/*immunology
MH  - Immunoglobulin G/*blood
MH  - Lagomorpha
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
EDAT- 1997/04/01 00:00
MHDA- 1998/11/13 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1998/11/13 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 1997 Apr;49(2):167-72.