PMID- 9813358
OWN - NLM
STAT- MEDLINE
DCOM- 19990210
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 812
IP  - 1-2
DP  - 1998 Nov 23
TI  - Depletion of dopamine in the nucleus accumbens prevents the generation of 
      locomotion by metabotropic glutamate receptor activation.
PG  - 260-4
AB  - The contribution of dopamine (DA) to the locomotion elicited by activation of 
      nucleus accumbens (NAcc) metabotropic glutamate receptors (mGluRs) was 
      investigated in the rat. Different groups of rats were pretreated with bilateral 
      microinjections of either 6-hydroxydopamine (6-OHDA) or its vehicle into the NAcc 
      and, on separate tests starting 10 days later, were tested for locomotion 
      following microinjections (into the same site) of saline, the mGluR agonist, 
      1-aminocyclopentane-trans-1,3-dicarboxylic acid [(1S, 3R)-ACPD, 0.5 nmol/side] 
      and amphetamine (AMPH, 6.8 nmol/side). DA levels at the microinjection sites were 
      significantly depleted in 6-OHDA-treated rats (42-99% depletions compared to 
      control values obtained in vehicle-treated rats). In contrast to the increased 
      locomotion observed in non-lesioned animals, rats pretreated with 6-OHDA showed 
      no increase in locomotor activity in response to (1S, 3R)-ACPD or AMPH when these 
      were microinjected into the NAcc. The two groups of rats were indistinguishable 
      when tested following NAcc saline. These findings suggest that, as with AMPH, 
      enhanced locomotion produced by NAcc mGluR activation is dependent on intact DA 
      neurotransmission in this site.
CI  - Copyright 1998 Elsevier Science B.V.
FAU - Meeker, D
AU  - Meeker D
AD  - Department of Psychiatry, The University of Chicago, 5841 S. Maryland Avenue, MC 
      3077, Chicago, IL 60637-1478, USA.
FAU - Kim, J H
AU  - Kim JH
FAU - Vezina, P
AU  - Vezina P
LA  - eng
GR  - DA-09860/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0TQU7668EI (Cycloleucine)
RN  - 111900-32-4 (1-amino-1,3-dicarboxycyclopentane)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - CK833KGX7E (Amphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Cycloleucine/analogs & derivatives/pharmacology
MH  - Dopamine/metabolism/*physiology
MH  - Locomotion/*physiology
MH  - Male
MH  - Microinjections
MH  - Nucleus Accumbens/*metabolism
MH  - Oxidopamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Metabotropic Glutamate/*agonists
EDAT- 1998/11/14 00:00
MHDA- 1998/11/14 00:01
CRDT- 1998/11/14 00:00
PHST- 1998/11/14 00:00 [pubmed]
PHST- 1998/11/14 00:01 [medline]
PHST- 1998/11/14 00:00 [entrez]
AID - S0006-8993(98)00941-X [pii]
AID - 10.1016/s0006-8993(98)00941-x [doi]
PST - ppublish
SO  - Brain Res. 1998 Nov 23;812(1-2):260-4. doi: 10.1016/s0006-8993(98)00941-x.