PMID- 9814650
OWN - NLM
STAT- MEDLINE
DCOM- 19990126
LR  - 20191102
IS  - 1065-6251 (Print)
IS  - 1065-6251 (Linking)
VI  - 5
IP  - 6
DP  - 1998 Nov
TI  - Current methodologies of human leukocyte antigen typing utilized for bone marrow 
      donor selection.
PG  - 419-28
AB  - Matching for human leukocyte antigen (HLA) loci is the most crucial factor in the 
      selection of bone marrow donors. The techniques utilized to assign HLA type have 
      evolved significantly since the application of polymerase chain reaction-based 
      methodologies. A significant challenge for DNA typing methodologies is to be able 
      to maintain high resolution typing with the ever-increasing numbers of defined 
      HLA alleles. To date, over 800 HLA class I and class II alleles have been 
      identified by sequencing analysis, and this number shows no sign of reaching a 
      plateau. It is only with high allelic level resolution typing analysis that an 
      accurate definition of the role that individual HLA loci play in determining 
      transplant outcome can be achieved, and this is a major goal for the future.
FAU - Little, A M
AU  - Little AM
AD  - Anthony Nolan Research Institute, The Royal Free Hospital School of Medicine, 
      London, UK.
FAU - Marsh, S G
AU  - Marsh SG
FAU - Madrigal, J A
AU  - Madrigal JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Hematol
JT  - Current opinion in hematology
JID - 9430802
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Bone Marrow Transplantation/*immunology
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Serology
MH  - *Tissue Donors
RF  - 77
EDAT- 1998/11/14 00:00
MHDA- 1998/11/14 00:01
CRDT- 1998/11/14 00:00
PHST- 1998/11/14 00:00 [pubmed]
PHST- 1998/11/14 00:01 [medline]
PHST- 1998/11/14 00:00 [entrez]
AID - 10.1097/00062752-199811000-00012 [doi]
PST - ppublish
SO  - Curr Opin Hematol. 1998 Nov;5(6):419-28. doi: 10.1097/00062752-199811000-00012.