PMID- 9815234
OWN - NLM
STAT- MEDLINE
DCOM- 19990107
LR  - 20220331
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 178
IP  - 6
DP  - 1998 Dec
TI  - Human herpesvirus 6 reactivation is associated with cytomegalovirus infection and 
      syndromes in kidney transplant recipients at risk for primary cytomegalovirus 
      infection.
PG  - 1783-6
AB  - A potential association between human herpesvirus 6 (HHV-6) and cytomegalovirus 
      (CMV) following kidney transplantation was explored by retrospectively testing 
      serial serum specimens for HHV-6 IgG and IgM antibody. HHV-6 reactivation 
      occurred in 35 (66%) of 53 transplant recipients. Fungal or parasitic 
      opportunistic infections, graft rejection or loss, and mortality were not 
      associated with HHV-6 reactivation. HHV-6 reactivation was associated with 
      primary CMV infection (P=.001) and CMV syndrome (P=.003) and with trends for 
      CMV-related hepatitis (P=.095), CMV-related neutropenia (P=.104), and serious CMV 
      disease (P=.085). After controlling for CMV immune globulin (CMVIG) prophylaxis, 
      the association between HHV-6 reactivation and primary CMV infection and syndrome 
      remained significant (P=.002 and 0.006, respectively). The reduction in CMV 
      syndrome among those receiving CMVIG prophylaxis remained significant (P=.007) 
      after controlling for HHV-6 reactivation. HHV-6 reactivation in kidney transplant 
      recipients at risk for primary CMV infection is associated with CMV infection and 
      CMV-related disease, and these effects are independent of CMVIG prophylaxis.
FAU - DesJardin, J A
AU  - DesJardin JA
AD  - Departments of Medicine and Pathology, New England Medical Center and Tuffs 
      University School of Medicine, Boston, MA 02111, USA.
FAU - Gibbons, L
AU  - Gibbons L
FAU - Cho, E
AU  - Cho E
FAU - Supran, S E
AU  - Supran SE
FAU - Falagas, M E
AU  - Falagas ME
FAU - Werner, B G
AU  - Werner BG
FAU - Snydman, D R
AU  - Snydman DR
LA  - eng
GR  - AI-07329/AI/NIAID NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Immunoglobulins)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 129L90A25N (cytomegalovirus-specific hyperimmune globulin)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Cytomegalovirus/immunology
MH  - Cytomegalovirus Infections/*complications/immunology/*prevention & control
MH  - Female
MH  - Hepatitis/epidemiology
MH  - Herpesviridae Infections/*complications/immunology/*physiopathology
MH  - Herpesvirus 6, Human/*growth & development/isolation & purification
MH  - Humans
MH  - *Immunization, Passive
MH  - Immunoglobulins
MH  - Immunoglobulins, Intravenous
MH  - *Kidney Transplantation
MH  - Male
MH  - Neutropenia/prevention & control
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Recurrence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Virus Activation
EDAT- 1998/11/17 03:02
MHDA- 2000/03/21 09:00
CRDT- 1998/11/17 03:02
PHST- 1998/11/17 03:02 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1998/11/17 03:02 [entrez]
AID - JID980432 [pii]
AID - 10.1086/314510 [doi]
PST - ppublish
SO  - J Infect Dis. 1998 Dec;178(6):1783-6. doi: 10.1086/314510.