PMID- 9820666
OWN - NLM
STAT- MEDLINE
DCOM- 19981201
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 96-97
DP  - 1998 Aug
TI  - Chromosome translocations detected by fluorescence in situ hybridisation 
      (FISH)--a useful tool in population monitoring?
PG  - 189-94
AB  - It is assumed that symmetrical translocations persist in peripheral lymphocytes 
      for years. For this reason, they should be valuable indicators especially for 
      chronic exposures of populations to mutagens or carcinogens. Reciprocal 
      translocations can be easily detected by means of fluorescence in situ 
      hybridization (FISH). Very little is known about the spontaneous frequency, which 
      forms the basis for population monitoring, and the variations which exist between 
      individuals. The frequencies obtained on the basis of structural chromosome 
      aberrations detected by means of FISH in 29 healthy persons are presented, and 
      the deviations in the occurrence of symmetrical translocations arising in the 
      different persons are indicated. Tests for the determination of persistence 
      levels, are carried out on persons exposed to radiation. The chromosomes 2, 4 and 
      8 are painted parallel to the centromeres, by means of the FISH technique.
FAU - Pressl, S
AU  - Pressl S
AD  - Institute for Radiation Hygiene, Federal Office for Radiation Protection, 
      Oberschleissheim, Germany.
FAU - Stephan, G
AU  - Stephan G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosomes, Human/radiation effects
MH  - DNA/genetics/radiation effects
MH  - Environmental Monitoring/*methods
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymphocytes/physiology/radiation effects/ultrastructure
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure
MH  - *Translocation, Genetic
EDAT- 1998/11/20 00:00
MHDA- 1998/11/20 00:01
CRDT- 1998/11/20 00:00
PHST- 1998/11/20 00:00 [pubmed]
PHST- 1998/11/20 00:01 [medline]
PHST- 1998/11/20 00:00 [entrez]
AID - S0378-4274(98)00068-X [pii]
AID - 10.1016/s0378-4274(98)00068-x [doi]
PST - ppublish
SO  - Toxicol Lett. 1998 Aug;96-97:189-94. doi: 10.1016/s0378-4274(98)00068-x.