PMID- 9823461
OWN - NLM
STAT- MEDLINE
DCOM- 19990120
LR  - 20191102
IS  - 1061-5385 (Print)
IS  - 1023-7046 (Linking)
VI  - 6
IP  - 2-3
DP  - 1998
TI  - Regulation of adhesion and migration in the germinal center microenvironment.
PG  - 111-6
AB  - T cell dependent humoral immune responses are initiated by the activation of 
      naive B cells in the T cell areas of the secondary lymphoid tissues. This primary 
      B cell activation leads to migration of germinal center (GC) cell precursors into 
      B cell follicles where they engage follicular dendritic cells (FDC) and T cells, 
      and differentiate into memory B cells or plasma cells. Both B cell homing to the 
      GC and interaction with FDC critically depend on integrin-mediated adhesion. We 
      have recently indentified the c-met-encoded receptor tyrosine kinase and its 
      ligand, the growth and motility factor hepatocyte growth factor/scatter factor 
      (HGF/SF), as a novel paracrine signalling pathway regulating B cell adhesion (van 
      der Voort et al., 1997, J. Exp. Med. 185, 2121-2131). The c-Met protein is 
      expressed on B cells localized in the dark zone of the GC (centroblasts) and is 
      induced by CD40 plus BCR ligation. Stimulation of c-Met with HGF/SF, which is 
      produced at high levels by tonsillar stromal cells and FDC, leads to receptor 
      phosphorylation and to enhanced integrin-mediated adhesion of B cells to both 
      VCAM-1 and fibronectin. Interestingly, these responses to HGF/SF are promoted by 
      heparan-sulfate proteoglycan forms of CD44 (CD44-HS). Like c-Met, CD44-HS is 
      induced on B cells by CD40 ligation. It efficiently binds HGF/SF and strongly 
      promotes signalling through c-Met. We conclude that integrin regulation during 
      antigen specific B cell differentiation involves cross-talk between the 
      HGF/SF-c-Met pathway and CD44-HS.
FAU - Pals, S T
AU  - Pals ST
AD  - Department of Pathology, Academic Medical Center, University of Amsterdam, The 
      Netherlands.
FAU - Taher, T E
AU  - Taher TE
FAU - van der Voort, R
AU  - van der Voort R
FAU - Smit, L
AU  - Smit L
FAU - Keehnen, R M
AU  - Keehnen RM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Cell Adhes Commun
JT  - Cell adhesion and communication
JID - 9417027
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/*cytology/*immunology
MH  - Cell Adhesion/immunology
MH  - Cell Movement/*immunology
MH  - Germinal Center/*cytology/*immunology
MH  - Humans
RF  - 67
EDAT- 1998/11/21 00:00
MHDA- 1998/11/21 00:01
CRDT- 1998/11/21 00:00
PHST- 1998/11/21 00:00 [pubmed]
PHST- 1998/11/21 00:01 [medline]
PHST- 1998/11/21 00:00 [entrez]
AID - 10.3109/15419069809004466 [doi]
PST - ppublish
SO  - Cell Adhes Commun. 1998;6(2-3):111-6. doi: 10.3109/15419069809004466.