PMID- 9823741
OWN - NLM
STAT- MEDLINE
DCOM- 19981211
LR  - 20190512
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 53
IP  - 6
DP  - 1998 Nov
TI  - Caloric restriction in rhesus monkeys reduces low density lipoprotein interaction 
      with arterial proteoglycans.
PG  - B443-8
AB  - Caloric restriction (CR) has been shown to retard aging processes in many 
      species. We investigated effects of CR on plasma low density lipoproteins (LDL), 
      a major risk factor for the age-associated process of atherosclerosis. Studies 
      emphasized effects of CR on LDL composition and their interaction with arterial 
      proteoglycans (PG). Rhesus monkeys were fed a control diet (n=13) or subjected to 
      CR (n=12 fed 30% less calories) for > 5 years. Plasma LDL cholesterol 
      concentrations were similar for control and CR groups (82+/-8 vs 72+/-6 mg/dL, 
      mean+/-SEM). LDL was isolated by ultracentrifugation and HPLC. LDL particles from 
      CR animals had a lower molecular weight (2.9+/-0.1 vs 3.2+/-0.1 g/micromol, p < 
      .05) and were depleted in triglyceride (249+/-16 vs 433+/-49 mol/particle, p < 
      .005) and phospholipid (686+/-20 vs 837+/-33 mol/particle, p <.001). Lower PG 
      binding was measured for LDL from CR animals (10.1+/-0.8 vs 15.6+/-1.1 microg LDL 
      cholesterol/microg PG, p <.005). This was associated with the lower triglycerides 
      (r=.76, p < .0005) and phospholipids (r=.48, p < .01). Thus, a dietary 
      intervention which may retard aging inhibits a proposed mechanism of 
      atherogenesis.
FAU - Edwards, I J
AU  - Edwards IJ
AD  - Department of Pathology, Wake Forest University School of Medicine, 
      Winston-Salem, North Carolina 27157, USA. iedwards@wfubmc.edu
FAU - Rudel, L L
AU  - Rudel LL
FAU - Terry, J G
AU  - Terry JG
FAU - Kemnitz, J W
AU  - Kemnitz JW
FAU - Weindruch, R
AU  - Weindruch R
FAU - Cefalu, W T
AU  - Cefalu WT
LA  - eng
GR  - AG00578/AG/NIA NIH HHS/United States
GR  - AG10816/AG/NIA NIH HHS/United States
GR  - AG14190/AG/NIA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Lipids)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Proteoglycans)
SB  - IM
MH  - Animals
MH  - Arteries/*metabolism
MH  - Drug Interactions
MH  - *Energy Intake
MH  - Lipids/blood
MH  - Lipoproteins, LDL/blood/chemistry/*physiology
MH  - Macaca mulatta
MH  - Proteoglycans/*physiology
EDAT- 1998/11/21 00:00
MHDA- 1998/11/21 00:01
CRDT- 1998/11/21 00:00
PHST- 1998/11/21 00:00 [pubmed]
PHST- 1998/11/21 00:01 [medline]
PHST- 1998/11/21 00:00 [entrez]
AID - 10.1093/gerona/53a.6.b443 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 1998 Nov;53(6):B443-8. doi: 
      10.1093/gerona/53a.6.b443.