PMID- 9824108
OWN - NLM
STAT- MEDLINE
DCOM- 19981124
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 29
IP  - 11
DP  - 1998 Nov
TI  - HIV-associated malignant lymphomas in Kenya (Equatorial Africa).
PG  - 1285-9
AB  - The clinical and pathological features of acquired immune deficiency syndrome 
      (AIDS)-related lymphomas, including their relationship with other viruses, such 
      as Epstein-Barr virus (EBV) and human herpes virus-8 (HHV8), have been the 
      subject of several studies from North America and Europe. No consistent data have 
      been reported in Africa, where AIDS runs an epidemiological and clinical course 
      different from that observed in Western countries. We retrospectively evaluated 
      the presence of human immunodeficiency virus (HIV), HHV8, and EBV in 146 cases of 
      malignant lymphomas collected in Kenya (Equatorial Africa), with the use of 
      polymerase chain reaction (PCR) and in situ hybridization (ISH). The PCR 
      technique confirmed HIV infection in 16 HIV-seropositive subjects (11%) and 
      showed the presence of HIV sequences in five additional cases (3%) in which the 
      occurrence of lymphoma was the only clinical manifestation. Our findings suggest 
      that AIDS-related lymphomas are not pathogenetically homogenous, and different 
      mechanisms may contribute to lymphomagenesis in these severely immunocompromised 
      patients. In our series, no association of Hodgkin's disease (HD) with HIV 
      infection could be shown. Among non-HIV-related lymphomas, EBV was present in 94% 
      of Burkitt lymphoma (BL) occurring in patients younger than 15 years of age, in 
      87% of HD independently of age, sex, and histological types, in 60% of anaplastic 
      large cell lymphoma (ALCL), and to a lesser extent (13%) in large B-cell lymphoma 
      (LBCL) cases. Only one tumor, a case of HD, showed HHV8 by PCR.
FAU - Lazzi, S
AU  - Lazzi S
AD  - Institute of Pathologic Anatomy and Histology, University of Siena, Italy.
FAU - Ferrari, F
AU  - Ferrari F
FAU - Nyongo, A
AU  - Nyongo A
FAU - Palummo, N
AU  - Palummo N
FAU - de Milito, A
AU  - de Milito A
FAU - Zazzi, M
AU  - Zazzi M
FAU - Leoncini, L
AU  - Leoncini L
FAU - Luzi, P
AU  - Luzi P
FAU - Tosi, P
AU  - Tosi P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
SB  - IM
CIN - Hum Pathol. 1999 Oct;30(10):1269-70. PMID: 10534180
MH  - HIV/*isolation & purification
MH  - Herpesvirus 4, Human/*isolation & purification
MH  - Herpesvirus 8, Human/*isolation & purification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Kenya/epidemiology
MH  - Lymphoma/metabolism/pathology/*virology
MH  - Lymphoma, AIDS-Related/*epidemiology/metabolism/pathology
MH  - Polymerase Chain Reaction
MH  - Retrospective Studies
MH  - Tumor Virus Infections/metabolism/pathology/*virology
EDAT- 1998/11/21 00:00
MHDA- 1998/11/21 00:01
CRDT- 1998/11/21 00:00
PHST- 1998/11/21 00:00 [pubmed]
PHST- 1998/11/21 00:01 [medline]
PHST- 1998/11/21 00:00 [entrez]
AID - S0046-8177(98)90258-1 [pii]
AID - 10.1016/s0046-8177(98)90258-1 [doi]
PST - ppublish
SO  - Hum Pathol. 1998 Nov;29(11):1285-9. doi: 10.1016/s0046-8177(98)90258-1.