PMID- 9826042
OWN - NLM
STAT- MEDLINE
DCOM- 19990113
LR  - 20190921
IS  - 1395-3907 (Print)
IS  - 1395-3907 (Linking)
VI  - 76
IP  - 5
DP  - 1998 Oct
TI  - Randomized study of the blood-aqueous barrier reaction after phacoemulsification 
      and extracapsular cataract extraction.
PG  - 573-8
AB  - PURPOSE: To compare the blood-aqueous barrier (BAB) breakdown after endocapsular 
      phacoemulsification and extracapsular cataract extraction (ECCE). METHODS: 
      Forty-two patients (64-82 years) enrolled for cataract surgery were randomly 
      assigned to phacoemulsification (group I) or ECCE (group II). Patients with 
      pseudoexfoliation syndrome, small pupils, glaucoma, uveitis, dark brown irides, 
      diabetes, treatment with eye drops or anti-inflammatory drugs were excluded. In 
      group I the patients were operated with continuous curvilinear capsulorhexis 
      (CCC), phacoemulsification and implantation of a poly-(methyl methacrylate) 
      (PMMA) intraocular lens (IOL) through a 5.2 mm self-sealing incision. In group II 
      linear capsulotomy, nucleus expression and PMMA IOL implantation through a large 
      incision (10-11 mm) were performed. The incision was sutured. Before surgery and 
      three days and three months after surgery postoperative inflammation and BAB 
      reaction were measured by laser flare photometry and anterior chamber 
      fluorophotometry after intravenous administration of fluorescein. The BAB 
      diffusion coefficient was calculated. Laser flare photometry was performed also 
      after one and two years. RESULTS: According to fluorophotometry, ECCE induced 
      significantly more postoperative BAB breakdown than did phacoemulsification at 
      three days (p=0.00016) and three months (p=0.00829). Laser flare photometry 
      showed more inflammation in the ECCE group than in the phacoemulsification group 
      at three days postoperatively (p=0.00005). CONCLUSIONS: This study suggests that 
      cataract surgery performed with a small, self-sealing incision, CCC and 
      phacoemulsification induces a reduced surgical trauma with less BAB breakdown 
      compared to ECCE using a large sutured incision, linear capsulotomy and nucleus 
      expression.
FAU - Laurell, C G
AU  - Laurell CG
AD  - St. Erik's Eye Hospital, Karolinska Institute, Stockholm, Sweden.
FAU - Zetterstrom, C
AU  - Zetterstrom C
FAU - Philipson, B
AU  - Philipson B
FAU - Syren-Nordqvist, S
AU  - Syren-Nordqvist S
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Ophthalmol Scand
JT  - Acta ophthalmologica Scandinavica
JID - 9507578
RN  - 0 (Contrast Media)
RN  - 9011-14-7 (Polymethyl Methacrylate)
RN  - TPY09G7XIR (Fluorescein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aqueous Humor/*metabolism
MH  - *Blood-Aqueous Barrier
MH  - *Capsulorhexis
MH  - Contrast Media/pharmacokinetics
MH  - Female
MH  - Fluorescein/pharmacokinetics
MH  - Fluorophotometry
MH  - Follow-Up Studies
MH  - Humans
MH  - Injections, Intravenous
MH  - Lens Implantation, Intraocular
MH  - Male
MH  - Middle Aged
MH  - *Phacoemulsification
MH  - Polymethyl Methacrylate
MH  - Visual Acuity
EDAT- 1998/11/24 00:00
MHDA- 1998/11/24 00:01
CRDT- 1998/11/24 00:00
PHST- 1998/11/24 00:00 [pubmed]
PHST- 1998/11/24 00:01 [medline]
PHST- 1998/11/24 00:00 [entrez]
AID - 10.1034/j.1600-0420.1998.760512.x [doi]
PST - ppublish
SO  - Acta Ophthalmol Scand. 1998 Oct;76(5):573-8. doi: 
      10.1034/j.1600-0420.1998.760512.x.