PMID- 9827056
OWN - NLM
STAT- MEDLINE
DCOM- 19981214
LR  - 20191102
IS  - 1367-8280 (Print)
IS  - 1367-8280 (Linking)
VI  - 120
IP  - 3
DP  - 1998 Oct
TI  - Growth regulation of cultured endothelial cells by inflammatory cytokines: 
      mitogenic, anti-proliferative and cytotoxic effects.
PG  - 397-404
AB  - The inflammatory cytokines tumor necrosis factor-alpha (TNF alpha) and 
      interleukin-1 alpha (IL-1 alpha) have angiogenic properties but generally inhibit 
      cultured endothelial cell (EC) proliferation. Investigations into the 
      growth-regulatory effects of these two agents on a variety of cultured EC types 
      showed that they exert mitogenic, anti-proliferative or cytotoxic effects 
      depending upon cell type and cytokine combinations. The anti-proliferative effect 
      was distinct from cytotoxicity. Nitric oxide (NO) release from EC, examined as a 
      potential mechanism underlying some of these effects, did not appear to mediate 
      the anti-proliferative effects of these cytokines. However, NO also seemed to 
      have a bimodal effect on EC proliferation depending upon whether the NO was 
      endogenous or exogenous. These data underscore the diversity in cytokine and NO 
      effects on cultured EC which, if reproducible in vivo, may be partly responsible 
      for the variable and sometimes contradictory results obtained with regards to the 
      role of inflammatory cytokines and NO on angiogenesis.
FAU - Gerol, M
AU  - Gerol M
AD  - Department of Pharmacology, Rush Medical College, Chicago, IL 60612, USA.
FAU - Curry, L
AU  - Curry L
FAU - McCarroll, L
AU  - McCarroll L
FAU - Doctrow, S
AU  - Doctrow S
FAU - RayChaudhury, A
AU  - RayChaudhury A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
JT  - Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & 
      endocrinology
JID - 9516060
RN  - 0 (Interleukin-1)
RN  - 0 (Mitogens)
RN  - 0 (Nitrates)
RN  - 0 (Nitrites)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - Brain/blood supply
MH  - Cattle
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Endothelium, Vascular/*drug effects/metabolism
MH  - Fibroblast Growth Factor 2/pharmacology
MH  - Humans
MH  - Interleukin-1/*pharmacology
MH  - Mitogens/*pharmacology
MH  - Nitrates/analysis
MH  - Nitric Oxide/metabolism
MH  - Nitrites/analysis
MH  - Pulmonary Artery
MH  - Rats
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1998/11/25 00:00
MHDA- 1998/11/25 00:01
CRDT- 1998/11/25 00:00
PHST- 1998/11/25 00:00 [pubmed]
PHST- 1998/11/25 00:01 [medline]
PHST- 1998/11/25 00:00 [entrez]
AID - 10.1016/s0742-8413(98)10064-6 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Oct;120(3):397-404. 
      doi: 10.1016/s0742-8413(98)10064-6.