PMID- 9827910
OWN - NLM
STAT- MEDLINE
DCOM- 19981229
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 103
IP  - 2
DP  - 1998 Nov
TI  - Effects of r-metHuG-CSF on polymorphonuclear leucocyte kinetics and function in 
      patients on continuous ambulatory peritoneal dialysis.
PG  - 387-96
AB  - End-stage renal failure (ESRF) patients undergoing continuous ambulatory 
      peritoneal dialysis (CAPD) are immunocompromised and exhibit abnormal circulating 
      polymorphonuclear leucocyte (PMN) function, including reduced phagocytosis and 
      intracellular killing. Six uraemic patients on CAPD were each given 300 microg 
      granulocyte colony stimulating factor (G-CSF) every day for 5 d and PMN function 
      tests were performed daily. By day 5 of the study CD11b expression was 
      significantly decreased in response to N-formylmethionylleucylphenylalanine 
      (fMLP) and opsonized Staphylococcus epidermidis stimulation, and expression of 
      L-selectin (CD62L) was significantly decreased in response to opsonized 
      Staphylococcus epidermidis stimulation. Further, superoxide anion production and 
      Fc gammaRI (CD64) expression were found to be significantly increased and Fc 
      gammaRII (CD16) expression was lowered. Circulating white cell and PMN counts 
      were significantly elevated in response to treatment. Administration of G-CSF did 
      not appear to have corrected the abnormalities in phagocytosis and intracellular 
      killing. This study suggests that G-CSF does no harm to ESRF patients and 
      influences uraemic PMN function in a manner that is comparable to its effects on 
      PMN in non-uraemic subjects.
FAU - Turzanski, J
AU  - Turzanski J
AD  - The David Evans Medical Research Centre, City Hospital NHS Trust, Nottingham.
FAU - Crouch, S P
AU  - Crouch SP
FAU - Andrews, M
AU  - Andrews M
FAU - Rose, M
AU  - Rose M
FAU - Finch, R
AU  - Finch R
FAU - Burden, R
AU  - Burden R
FAU - Holliday, M
AU  - Holliday M
FAU - Fletcher, J
AU  - Fletcher J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Antigens, Surface)
RN  - 0 (Recombinant Proteins)
RN  - 11062-77-4 (Superoxides)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - PVI5M0M1GW (Filgrastim)
SB  - IM
MH  - Adult
MH  - Antigens, Surface/metabolism
MH  - Cell Culture Techniques
MH  - Cell Death/immunology
MH  - Filgrastim
MH  - Granulocyte Colony-Stimulating Factor/adverse effects/*pharmacology
MH  - Humans
MH  - Kidney Failure, Chronic/immunology/therapy
MH  - Leukocyte Count
MH  - Middle Aged
MH  - Neutrophils/*immunology
MH  - Peritoneal Cavity/pathology
MH  - *Peritoneal Dialysis, Continuous Ambulatory
MH  - Phagocytosis
MH  - Recombinant Proteins
MH  - Superoxides/metabolism
EDAT- 1998/11/25 00:00
MHDA- 1998/11/25 00:01
CRDT- 1998/11/25 00:00
PHST- 1998/11/25 00:00 [pubmed]
PHST- 1998/11/25 00:01 [medline]
PHST- 1998/11/25 00:00 [entrez]
AID - 10.1046/j.1365-2141.1998.01019.x [doi]
PST - ppublish
SO  - Br J Haematol. 1998 Nov;103(2):387-96. doi: 10.1046/j.1365-2141.1998.01019.x.