PMID- 9829581
OWN - NLM
STAT- MEDLINE
DCOM- 19981214
LR  - 20161124
IS  - 0161-5505 (Print)
IS  - 0161-5505 (Linking)
VI  - 39
IP  - 11
DP  - 1998 Nov
TI  - Indium-111-DTPA-D-Phe-1-octreotide and technetium-99m-(V)-dimercaptosuccinic acid 
      scanning in the preoperative staging of medullary thyroid carcinoma.
PG  - 1907-9
AB  - The early detection of all tumor sites in patients with medullary thyroid 
      carcinoma (MTC) before primary surgery is important, because MTC tends to 
      metastasize to regional lymph nodes of the neck and mediastinum early during the 
      course of the disease. METHODS: In an approach to localize the primary tumor 
      sites and to detect additional tumor involvement, we have performed in 22 
      patients with MTC either 99mTc(V)-dimercaptosuccinic acid (DMSA) and/or 
      111In-diethylenetriamine pentaacetic acid-D-Phe-1-octreotide scintigraphy. 
      RESULTS: Indium-111-octreotide (150-200 MBq) identified the primary tumor in 10 
      of 14 patients (71%), whereas the primary tumor was visualized by 99mTc-DMSA 
      (300-370 MBq) in 10 of 17 patients (58%). In 8 of 22 patients (36%), lymph node 
      metastases were present at the time of diagnosis, as confirmed by histopathology 
      and histochemistry after surgery (all <2 mm). Preoperatively, neither scan was 
      able to detect lymph node involvement in these patients (0/8). CONCLUSION: Both 
      99mTc-DMSA and 111In-octreotide studies have similar sensitivity to localize 
      primary MTC; however, these scans are not able to detect small lymph node 
      involvement (micrometastases) before initial surgery. Unfortunately, both scans 
      have no clinical implication for preoperative staging in patients with MTC.
FAU - Kurtaran, A
AU  - Kurtaran A
AD  - Department of Nuclear Medicine, University of Vienna, Austria.
FAU - Scheuba, C
AU  - Scheuba C
FAU - Kaserer, K
AU  - Kaserer K
FAU - Schima, W
AU  - Schima W
FAU - Czerny, C
AU  - Czerny C
FAU - Angelberger, P
AU  - Angelberger P
FAU - Niederle, B
AU  - Niederle B
FAU - Virgolini, I
AU  - Virgolini I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Nucl Med
JT  - Journal of nuclear medicine : official publication, Society of Nuclear Medicine
JID - 0217410
RN  - 0 (Indium Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Receptors, Somatostatin)
RN  - 142694-57-3 (SDZ 215-811)
RN  - 494JNQ8L28 (Technetium Tc 99m Dimercaptosuccinic Acid)
RN  - 7A314HQM0I (Pentetic Acid)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - Carcinoma, Medullary/*diagnostic imaging/secondary/surgery
MH  - Female
MH  - Humans
MH  - *Indium Radioisotopes
MH  - Lymph Nodes/diagnostic imaging
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Octreotide/*analogs & derivatives
MH  - Pentetic Acid/*analogs & derivatives
MH  - Preoperative Care
MH  - Radionuclide Imaging
MH  - *Radiopharmaceuticals
MH  - Receptors, Somatostatin/analysis
MH  - Sensitivity and Specificity
MH  - *Technetium Tc 99m Dimercaptosuccinic Acid
MH  - Thyroid Neoplasms/*diagnostic imaging/pathology/surgery
EDAT- 1998/11/26 00:00
MHDA- 1998/11/26 00:01
CRDT- 1998/11/26 00:00
PHST- 1998/11/26 00:00 [pubmed]
PHST- 1998/11/26 00:01 [medline]
PHST- 1998/11/26 00:00 [entrez]
PST - ppublish
SO  - J Nucl Med. 1998 Nov;39(11):1907-9.