PMID- 9833216
OWN - NLM
STAT- MEDLINE
DCOM- 19990125
LR  - 20190915
IS  - 0937-4477 (Print)
IS  - 0937-4477 (Linking)
VI  - 255
IP  - 9
DP  - 1998
TI  - The effect of interleukin-6 on enhancing the invasiveness of head and neck cancer 
      cells in vitro.
PG  - 468-72
AB  - Patients with head and neck cancers that produce a high concentration of 
      granulocyte colony-stimulating factor (G-CSF) or patients with esophageal 
      squamous cell carcinomas who have elevated serum interleukin-6 (IL-6) 
      concentrations have been found previously to be at significant risk for tumor 
      invasion to adjacent organs as well as frequent metastases. This suggests that 
      G-CSF and Il-6 enhance the invasiveness and metastatic potential of cancer cells. 
      We studied the in vitro invasiveness of head and neck cancer cell lines with and 
      without recombinant human G-CSF (rhG-CSF) and human IL-6 (hIL-6) in an 
      extracellular matrix membrane system. The degree of invasiveness was affected by 
      incubating cells with hIL-6, but not by pre-incubating the cell-matrix with 
      hIL-6. The maximum concentration of hIL-6 for enhanced invasiveness was 
      approximately 5,000 u/ml. In addition, rhG-CSF enhanced the invasiveness of tumor 
      cells that produced large amounts of G-CSF. The present study also suggests that 
      tumor cells tend to invade and metastasize in an environment rich in hIL-6.
FAU - Nishino, H
AU  - Nishino H
AD  - Department of Otolaryngology, Jichi Medical School, Tochigi, Japan.
FAU - Miyata, M
AU  - Miyata M
FAU - Kitamura, K
AU  - Kitamura K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Culture Media)
RN  - 0 (Interleukin-6)
RN  - 0 (Recombinant Proteins)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Culture Media
MH  - Dose-Response Relationship, Drug
MH  - Granulocyte Colony-Stimulating Factor/pharmacology
MH  - Head and Neck Neoplasms/*pathology
MH  - Humans
MH  - Interleukin-6/*pharmacology
MH  - Neoplasm Invasiveness
MH  - Recombinant Proteins
MH  - Stimulation, Chemical
MH  - Tumor Cells, Cultured
EDAT- 1998/12/02 00:00
MHDA- 1998/12/02 00:01
CRDT- 1998/12/02 00:00
PHST- 1998/12/02 00:00 [pubmed]
PHST- 1998/12/02 00:01 [medline]
PHST- 1998/12/02 00:00 [entrez]
AID - 10.1007/s004050050101 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 1998;255(9):468-72. doi: 10.1007/s004050050101.