PMID- 9834364
OWN - NLM
STAT- MEDLINE
DCOM- 20061212
LR  - 20191102
IS  - 1091-255X (Print)
IS  - 1091-255X (Linking)
VI  - 1
IP  - 4
DP  - 1997 Jul-Aug
TI  - Expression and prognostic significance of HLA class I, ICAM-1, and 
      tumor-infiltrating lymphocytes in esophageal cancer.
PG  - 316-23
AB  - Most solid malignancies show some degree of lymphoid infiltration suggesting a 
      specific immunologic host vs. tumor reaction. Tumor-infiltrating lymphocytes 
      (i.e., CD3 + T-lymphocyte subsets), the human leukocyte antigen (HLA) class I 
      molecules, and the intercellular adhesion molecule-1 (ICAM-1) are key factors 
      involved in T-cell-mediated immune surveillance. The present study was designed 
      to assess the expression pattern of intratumoral lymphocyte infiltrates and their 
      relationship to HLA class I and ICAM-1 expression with regard to primary 
      esophageal carcinoma and to evaluate their prognostic influence. Representative 
      samples of primary tumors were obtained from 55 patients who had undergone 
      radical en bloc esophagectomy. Frozen sections of these tumors were stained with 
      monoclonal antibodies directed against CD3 for the assessment of 
      tumor-infiltrating lymphocytes, HLA class I, and ICAM-1. The mean postoperative 
      observation period was 19.5 months (range 5 to 45 months). Lymphocyte 
      infiltration was absent in four tumors (8%), whereas 31 tumors (64%) showed 
      moderate and 13 (27%) showed strong infiltration. HLA class I expression was 
      deficient in 24 tumors (45%). Coexpression of HLA class I and ICAM-1 was 
      significantly associated with lymphocyte infiltration of the tumor. Kaplan-Meier 
      analyses revealed a significant beneficial influence on relapse-free survival for 
      patients with lymphocyte infiltration of primary tumors compared to those with no 
      lymphocyte infiltration of tumors (median 4 months vs. 18 months; P <0.002) and 
      for HLA class I+ tumors compared to HLA class I- tumors (median survival >18 
      months vs. 7 months; P = 0.0081). The present data support the hypothesis that 
      T-cell-mediated immunity may influence the fate of patients with esophageal 
      cancer.
FAU - Hosch, S B
AU  - Hosch SB
AD  - Abteilung fur Allgemeinchirurgie, Universitats-Krankenhaus Eppendorf, Universitat 
      Hamburg, Hamburg, Germany.
FAU - Meyer, A J
AU  - Meyer AJ
FAU - Schneider, C
AU  - Schneider C
FAU - Stoecklein, N
AU  - Stoecklein N
FAU - Prenzel, K L
AU  - Prenzel KL
FAU - Pantel, K
AU  - Pantel K
FAU - Broelsch, C E
AU  - Broelsch CE
FAU - Izbicki, J R
AU  - Izbicki JR
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery 
      of the Alimentary Tract
JID - 9706084
RN  - 0 (CD3 Complex)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - CD3 Complex/analysis
MH  - Carcinoma/mortality/*pathology/surgery
MH  - Disease-Free Survival
MH  - Esophageal Neoplasms/mortality/*pathology/surgery
MH  - Female
MH  - HLA Antigens/*analysis
MH  - Histocompatibility Antigens Class I/*analysis
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*analysis
MH  - Lymphocytes, Tumor-Infiltrating/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Survival Rate
EDAT- 1997/07/01 00:00
MHDA- 1998/12/03 00:00
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1998/12/03 00:00 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - S1091-255X(97)80051-0 [pii]
AID - 10.1016/s1091-255x(97)80051-0 [doi]
PST - ppublish
SO  - J Gastrointest Surg. 1997 Jul-Aug;1(4):316-23. doi: 
      10.1016/s1091-255x(97)80051-0.