PMID- 9839864
OWN - NLM
STAT- MEDLINE
DCOM- 19990204
LR  - 20061115
IS  - 0928-7329 (Print)
IS  - 0928-7329 (Linking)
VI  - 6
IP  - 2-3
DP  - 1998 Sep
TI  - Protein and cell engineering of components of the human immunoglobulin E 
      receptor/effector system: applications for therapy and diagnosis.
PG  - 195-207
AB  - Adaptive immune responses characterised by the synthesis of antibodies of the 
      immunoglobulin E (IgE) isotype play an important role in type I hypersensitivity 
      disorders and parasitic infestations, diseases which have an significant 
      socioeconomic impact world-wide. This paper considers potential applications of 
      recent advances in our understanding of the origin of isotype specific immune 
      responses which emerged as a result of cell and protein engineering studies on 
      components of the human IgE/receptor/effector system. Furthermore, the 
      identification of the receptor binding regions in IgE as a result of the 
      development of a stable assay system has important applications for the design of 
      rational therapeutic interventions in allergy and asthma, the treatment of mast 
      cell tumours, and the establishment of procedures for the selective isolation of 
      cells expressing the high-affinity receptor for IgE for functional studies.
FAU - Helm, B A
AU  - Helm BA
AD  - Krebs Institute for Biomolecular Research, Department of Molecular Biology and 
      Biotechnology, The University of Sheffield, UK. B.Helm@Sheffield.AC.UK
FAU - Sayers, I
AU  - Sayers I
FAU - Swan, J
AU  - Swan J
FAU - Smyth, L J
AU  - Smyth LJ
FAU - Cain, S A
AU  - Cain SA
FAU - Suter, M
AU  - Suter M
FAU - Machado, D C
AU  - Machado DC
FAU - Spivey, A C
AU  - Spivey AC
FAU - Padlan, E A
AU  - Padlan EA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Technol Health Care
JT  - Technology and health care : official journal of the European Society for 
      Engineering and Medicine
JID - 9314590
RN  - 0 (Antibodies)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies/*chemistry
MH  - Cell Line
MH  - *Drug Design
MH  - Humans
MH  - Hypersensitivity, Immediate/diagnosis/*immunology/therapy
MH  - Immunoglobulin E/*chemistry/*immunology
MH  - Mast Cells/immunology
MH  - Parasitic Diseases/diagnosis/*immunology/therapy
MH  - Protein Engineering/*methods
MH  - Rats
MH  - Receptors, IgE/*chemistry
EDAT- 1998/12/05 00:00
MHDA- 1998/12/05 00:01
CRDT- 1998/12/05 00:00
PHST- 1998/12/05 00:00 [pubmed]
PHST- 1998/12/05 00:01 [medline]
PHST- 1998/12/05 00:00 [entrez]
PST - ppublish
SO  - Technol Health Care. 1998 Sep;6(2-3):195-207.