PMID- 9842009
OWN - NLM
STAT- MEDLINE
DCOM- 19990107
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 136
IP  - 6
DP  - 1998 Dec
TI  - Coronary vasodilator reserve is impaired in patients with hypertrophic 
      cardiomyopathy and left ventricular dysfunction.
PG  - 972-81
AB  - BACKGROUND: We tested the hypothesis that a reduced delivery of blood to the 
      myocardium is involved in the development of systolic dysfunction of patients 
      with hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: Eighty-four patients 
      with HCM (62 men, age 43 +/- 12 years) were studied. Left ventricular dimensions 
      and function (fractional shortening) were evaluated by 2-dimensional 
      echocardiography. Myocardial blood flow (MBF) was measured by N13 -ammonia or O15 
      -water and positron emission tomography at baseline and after dipyridamole; 
      coronary vasodilator reserve (CVR) was calculated as dipyridamole/baseline MBF. 
      Patients with HCM in advanced New York Heart Association (NYHA) classes had lower 
      dipyridamole MBF (NYHA class I = 1.57 +/- 0.64 vs class II = 1.52 +/- 0.58 vs 
      class III = 0.96 +/- 0.32 mL/min per gram; analysis of variance, P <.05) and CVR 
      (NYHA class I = 1.93 +/- 0.64 vs class II = 1.69 +/- 0.54 vs class III = 1.40 +/- 
      0.43; analysis of variance, P <.05). A positive linear correlation between 
      fractional shortening and dipyridamole MBF was demonstrated (R = 0.23, P <.05), 
      and patients with abnormal fractional shortening had lower dipyridamole MBF (1.07 
      +/- 0.43 vs 1.58 +/- 0.62 mL/min per gram, P <.01). CONCLUSIONS: Systolic 
      dysfunction in HCM may be caused by a more severe alteration of the coronary 
      vasodilator capacity.
FAU - Lorenzoni, R
AU  - Lorenzoni R
AD  - MRC Clinical Sciences Centre and Royal Postgraduate Medical School, Hammersmith 
      Hospital, London, UK.
FAU - Gistri, R
AU  - Gistri R
FAU - Cecchi, F
AU  - Cecchi F
FAU - Olivotto, I
AU  - Olivotto I
FAU - Chiriatti, G
AU  - Chiriatti G
FAU - Elliott, P
AU  - Elliott P
FAU - McKenna, W J
AU  - McKenna WJ
FAU - Camici, P G
AU  - Camici PG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Hypertrophic/complications/diagnostic imaging/*physiopathology
MH  - *Coronary Circulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regional Blood Flow
MH  - Tomography, Emission-Computed
MH  - Ultrasonography
MH  - Ventricular Dysfunction, Left/complications/diagnostic imaging/*physiopathology
EDAT- 1998/12/08 00:00
MHDA- 1998/12/08 00:01
CRDT- 1998/12/08 00:00
PHST- 1998/12/08 00:00 [pubmed]
PHST- 1998/12/08 00:01 [medline]
PHST- 1998/12/08 00:00 [entrez]
AID - S000287039800012X [pii]
AID - 10.1016/s0002-8703(98)70152-8 [doi]
PST - ppublish
SO  - Am Heart J. 1998 Dec;136(6):972-81. doi: 10.1016/s0002-8703(98)70152-8.