PMID- 9844599
OWN - NLM
STAT- MEDLINE
DCOM- 19981210
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 107
IP  - 2
DP  - 1998 Dec
TI  - Detection of chromosome 6 abnormalities in melanoma cell lines by chromosome arm 
      painting probes.
PG  - 89-92
AB  - Chromosome 6 abnormalities, particularly the deletion of 6q, are among the most 
      frequent chromosomal changes in human malignant melanoma. In this study, 
      chromosome 6 rearrangements in 21 melanoma cell lines were identified by 
      fluorescence in situ hybridization (FISH) with the use of chromosome 6 arm 
      specific painting probes (CAPs). Structural abnormalities of chromosome 6 were 
      detectable in 18 of 21 (86%) cases, including the identification of structural 
      abnormalities that were not detectable by routine G-banding analysis. The results 
      of this study correlate the frequency of 6q alterations and demonstrate that FISH 
      with CAPs can be of considerable use for rapid screening of specific chromosome 
      abnormalities in melanoma.
FAU - Guan, X Y
AU  - Guan XY
AD  - Cancer Genetics Branch, National Human Genome Research Institute, National 
      Institutes of Health, Bethesda, MD 20892-4470, USA.
FAU - Zhang, H
AU  - Zhang H
FAU - Yang, J M
AU  - Yang JM
FAU - Wang, J
AU  - Wang J
FAU - Taetle, R
AU  - Taetle R
FAU - Meltzer, P S
AU  - Meltzer PS
FAU - Trent, J M
AU  - Trent JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Chromosome Aberrations/*diagnosis
MH  - Chromosome Disorders
MH  - Chromosome Painting/*methods
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Gene Deletion
MH  - Humans
MH  - Melanoma/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1998/12/09 00:00
MHDA- 1998/12/09 00:01
CRDT- 1998/12/09 00:00
PHST- 1998/12/09 00:00 [pubmed]
PHST- 1998/12/09 00:01 [medline]
PHST- 1998/12/09 00:00 [entrez]
AID - S0165460898000806 [pii]
AID - 10.1016/s0165-4608(98)00080-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1998 Dec;107(2):89-92. doi: 
      10.1016/s0165-4608(98)00080-6.