PMID- 9844603
OWN - NLM
STAT- MEDLINE
DCOM- 19981210
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 107
IP  - 2
DP  - 1998 Dec
TI  - Interstitial insertion of AF10 into the ALL1 gene in a case of infant acute 
      lymphoblastic leukemia.
PG  - 107-10
AB  - The ALL1 gene at 11q23 is a promiscuous gene participating in chromosomal 
      abnormalities of acute leukemias with 1 of over 30 potential partner genes. Among 
      these, the AF10 gene at band 10p12 has been recently cloned and characterized. 
      Acute leukemias with the ALL1/AF10 chimeric gene frequently show heterogeneity in 
      the breakpoints on 10p, as well as complex insertion (10;11) as a result of 
      complex molecular mechanisms leading to the ALL1/AF10 fusion. In this context, we 
      report the first description of an infant acute lymphoblastic leukemia with an 
      interstitial insertion of the AF10 gene into the 11q23 band, resulting in the 
      transcription of the ALL1/AF10 fusion product. Furthermore, we show how different 
      diagnostic tools such as molecular, cytogenetic, and fluorescence in situ 
      hybridization (FISH) analyses should be combined to resolve complex situations in 
      the 11q23 setting.
FAU - Angioni, A
AU  - Angioni A
AD  - Servizio Immunotrasfusionale, Ospedale Bambino Gesu, IRCCS, Rome, Italy.
FAU - La Starza, R
AU  - La Starza R
FAU - Mecucci, C
AU  - Mecucci C
FAU - Sprovieri, T
AU  - Sprovieri T
FAU - Matteucci, C
AU  - Matteucci C
FAU - De Rossi, G
AU  - De Rossi G
FAU - Balloni, P
AU  - Balloni P
FAU - Cimino, G
AU  - Cimino G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (MLLT10 protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Chromosomes, Human, Pair 10/*genetics
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - DNA-Binding Proteins/analysis/*genetics
MH  - Female
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant, Newborn
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - Oncogene Proteins, Fusion/analysis/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Proto-Oncogenes
MH  - Transcription Factors/analysis/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 1998/12/09 00:00
MHDA- 1998/12/09 00:01
CRDT- 1998/12/09 00:00
PHST- 1998/12/09 00:00 [pubmed]
PHST- 1998/12/09 00:01 [medline]
PHST- 1998/12/09 00:00 [entrez]
AID - S0165460898001058 [pii]
AID - 10.1016/s0165-4608(98)00105-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1998 Dec;107(2):107-10. doi: 
      10.1016/s0165-4608(98)00105-8.