PMID- 9846823
OWN - NLM
STAT- MEDLINE
DCOM- 19981217
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 91
IP  - 1-2
DP  - 1998 Nov 2
TI  - Development of HIV encephalitis in AIDS and TNF-alpha regulatory elements.
PG  - 89-92
AB  - Tumor necrosis factor-alpha (TNF-alpha) appears to play an important role in HIV 
      encephalitis (HIVE). TNF2, a polymorphism of TNF-alpha, associates with higher 
      levels of TNF-alpha and severe manifestations of some infections. We studied 44 
      acquired immunodeficiency syndrome (AIDS) patients with autopsy-proven HIVE 
      and/or HIV leukoencephalopathy (HIVLE) (HIVE/LE) and 30 AIDS patients without 
      HIVE/LE. TNF2 did not associate with presence of HIVE/LE (p > 0.5). Moreover, the 
      TNF-alpha regulatory element TTATTTAT within the 3'-untranslated region was 
      intact in HIVE/LE brains, and HLA-DR3 did not associate with HIVE/LE. Other host 
      factors or, more likely, viral factors may be responsible for the development of 
      HIVE/LE.
FAU - Sato-Matsumura, K C
AU  - Sato-Matsumura KC
AD  - Institute of Neurology, University of Vienna, Austria.
FAU - Berger, J
AU  - Berger J
FAU - Hainfellner, J A
AU  - Hainfellner JA
FAU - Mazal, P
AU  - Mazal P
FAU - Budka, H
AU  - Budka H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - AIDS Dementia Complex/*immunology
MH  - Alleles
MH  - Antibodies, Viral/immunology
MH  - Brain/immunology/virology
MH  - Encephalitis, Viral/*immunology
MH  - *HIV
MH  - HLA-DR3 Antigen/analysis
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/*immunology
EDAT- 1998/12/10 03:02
MHDA- 2000/06/01 09:00
CRDT- 1998/12/10 03:02
PHST- 1998/12/10 03:02 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1998/12/10 03:02 [entrez]
AID - S0165-5728(98)00161-1 [pii]
AID - 10.1016/s0165-5728(98)00161-1 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1998 Nov 2;91(1-2):89-92. doi: 10.1016/s0165-5728(98)00161-1.