PMID- 9846826
OWN - NLM
STAT- MEDLINE
DCOM- 19981217
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 91
IP  - 1-2
DP  - 1998 Nov 2
TI  - No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES 
      mRNA in blood and CSF in multiple sclerosis.
PG  - 108-12
AB  - The perivascular accumulation of mononuclear cells (MNC) in brain white matter is 
      critical in the development of active lesions in multiple sclerosis (MS). 
      Chemokines contribute to leukocyte recruitment by increasing the adhesiveness of 
      integrins expressed on leukocytes and by promoting migration through endothelium 
      and extracellular matrix. By using an in situ hybridization technique, it was 
      possible to enumerate blood and CSF MNC expressing mRNA for the two CC chemokines 
      monocyte chemoattractant protein-1 (MCP-1) and RANTES (regulated upon activation, 
      normal T cells, expressed and secreted) in MS patients and controls. No 
      differences in numbers of blood MNC expressing MCP-1 or RANTES could be found in 
      MS patients compared to healthy individuals or patients with acute aseptic 
      meningoencephalitis (AM). High numbers of CSF MNC expressing MCP-1 and RANTES 
      were found in some MS patients, but also in patients with AM. This shows that 
      elevated numbers of MCP-1 and RANTES mRNA expressing CSF MNC are not specific for 
      the inflammatory process in MS. We conclude that there is no evidence for a 
      systemic dysregulation of the CC chemokines MCP-1 and RANTES in MS.
FAU - Kivisakk, P
AU  - Kivisakk P
AD  - Division of Neurology, Karolinska Institute, Huddinge University Hospital, 
      Stockholm, Sweden. Pia.Kivisakk@cnsf.ki.se
FAU - Teleshova, N
AU  - Teleshova N
FAU - Ozenci, V
AU  - Ozenci V
FAU - Huang, Y
AU  - Huang Y
FAU - Matusevicius, D
AU  - Matusevicius D
FAU - Fredrikson, S
AU  - Fredrikson S
FAU - Soderstrom, M
AU  - Soderstrom M
FAU - Link, H
AU  - Link H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemokine CCL2/*genetics/immunology
MH  - Chemokine CCL5/*genetics/immunology
MH  - Female
MH  - Gene Expression/immunology
MH  - Humans
MH  - Leukocytes, Mononuclear/chemistry/*immunology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*immunology
MH  - RNA, Messenger/blood/cerebrospinal fluid
EDAT- 1998/12/10 03:02
MHDA- 2000/06/01 09:00
CRDT- 1998/12/10 03:02
PHST- 1998/12/10 03:02 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1998/12/10 03:02 [entrez]
AID - S0165-5728(98)00158-1 [pii]
AID - 10.1016/s0165-5728(98)00158-1 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1998 Nov 2;91(1-2):108-12. doi: 10.1016/s0165-5728(98)00158-1.