PMID- 9847383
OWN - NLM
STAT- MEDLINE
DCOM- 19990128
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 73
IP  - 1
DP  - 1999 Jan
TI  - Human herpesvirus 6 latently infects early bone marrow progenitors in vivo.
PG  - 754-9
AB  - We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for 
      hemopoietic cells in patients with latent HHV-6 infection. Having used a variety 
      of cell purification, molecular, cytogenetic, and immunocytochemical procedures, 
      we report the first evidence that HHV-6 latently infects early bone marrow 
      progenitor cells and that HHV-6 may be transmitted longitudinally to cells which 
      differentiate along the committed pathways.
FAU - Luppi, M
AU  - Luppi M
AD  - Section of Hematology, Department of Medical Sciences, University of Modena, 
      Modena, Italy.
FAU - Barozzi, P
AU  - Barozzi P
FAU - Morris, C
AU  - Morris C
FAU - Maiorana, A
AU  - Maiorana A
FAU - Garber, R
AU  - Garber R
FAU - Bonacorsi, G
AU  - Bonacorsi G
FAU - Donelli, A
AU  - Donelli A
FAU - Marasca, R
AU  - Marasca R
FAU - Tabilio, A
AU  - Tabilio A
FAU - Torelli, G
AU  - Torelli G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antigens, CD34)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Antigens, CD34/analysis
MH  - Bone Marrow Cells/*virology
MH  - DNA, Viral/analysis
MH  - Hematopoietic Stem Cells/*virology
MH  - Herpesviridae Infections/*virology
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - *Virus Latency
PMC - PMC103884
EDAT- 1998/12/16 00:00
MHDA- 1998/12/16 00:01
PMCR- 1999/01/01
CRDT- 1998/12/16 00:00
PHST- 1998/12/16 00:00 [pubmed]
PHST- 1998/12/16 00:01 [medline]
PHST- 1998/12/16 00:00 [entrez]
PHST- 1999/01/01 00:00 [pmc-release]
AID - 0988 [pii]
AID - 10.1128/JVI.73.1.754-759.1999 [doi]
PST - ppublish
SO  - J Virol. 1999 Jan;73(1):754-9. doi: 10.1128/JVI.73.1.754-759.1999.