PMID- 9850848
OWN - NLM
STAT- MEDLINE
DCOM- 19990322
LR  - 20190915
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 165
DP  - 1998 Oct
TI  - Role of interleukin-7 in T-cell development from hematopoietic stem cells.
PG  - 13-28
AB  - All lymphocytes are derived from hematopoietic stem cells (HSC). The 
      interleukin-7 receptor (IL-7R) transduces non-redundant signals for both T and 
      B-cell development from HSC. The upregulation of the IL-7R occurs at the stage of 
      the clonogenic common lymphoid progenitor, a recently identified population that 
      can give rise to all lymphoid lineages (T, B and natural killer cells) at a 
      single cell level. The IL-7R plays a critical role in the rearrangement of 
      immunoglobulin heavy chain genes required for B-cell development. IL-7R 
      expression is critically regulated in developing thymocytes; thymocytes that fail 
      the positive selection process downregulate the IL-7R, but those undergoing 
      positive selection upregulate or maintain IL-7R expression. Recent data indicate 
      that IL-7 signaling enhances the survival of developing thymocytes and mature T 
      cells, presumably by its upregulating Bcl-2. Detailed analysis of the signaling 
      cascades activated by the IL-7R may help to reveal the differential roles of IL-7 
      signaling in T and B-cell development.
FAU - Akashi, K
AU  - Akashi K
AD  - Department of Pathology, Standford University School of Medicine 94305, USA. 
      Akashi@Darwin.Stanford.edu
FAU - Kondo, M
AU  - Kondo M
FAU - Weissman, I L
AU  - Weissman IL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Interleukin-7)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/cytology
MH  - Cell Differentiation
MH  - Genes, Immunoglobulin
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Interleukin-7/*physiology
MH  - Lymphocytes
MH  - Receptors, Antigen, T-Cell, alpha-beta
MH  - Receptors, Interleukin-7/physiology
MH  - Recombination, Genetic
MH  - Signal Transduction
MH  - T-Lymphocytes/*cytology/physiology
MH  - Thymus Gland/cytology
RF  - 137
EDAT- 1998/12/16 00:00
MHDA- 1998/12/16 00:01
CRDT- 1998/12/16 00:00
PHST- 1998/12/16 00:00 [pubmed]
PHST- 1998/12/16 00:01 [medline]
PHST- 1998/12/16 00:00 [entrez]
AID - 10.1111/j.1600-065x.1998.tb01226.x [doi]
PST - ppublish
SO  - Immunol Rev. 1998 Oct;165:13-28. doi: 10.1111/j.1600-065x.1998.tb01226.x.