PMID- 9851538
OWN - NLM
STAT- MEDLINE
DCOM- 19990304
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 361
IP  - 1
DP  - 1998 Nov 13
TI  - Antipsychotic drugs induce similar effects on the release of dopamine and 
      noradrenaline in the medial prefrontal cortex of the rat brain.
PG  - 27-33
AB  - In the present study we have compared the effects of the classical antipsychotic 
      drug haloperidol and four different atypical antipsychotics (clozapine, 
      risperidone, olanzapine, ziprasidone) on extracellular levels of dopamine and 
      noradrenaline in the medial prefrontal cortex (MPFC) of conscious rats. 
      Haloperidol (10, 100 and 800 nmol/kg), clozapine (0.3, 1, 10 and 30 micromol/kg), 
      risperidone (100, 500 and 5000 nmol/kg), olanzapine (10, 100 and 500 nmol/kg) and 
      ziprasidone (10, 100 and 1000 nmol/kg) were administered subcutaneously to rats. 
      All compounds induced increases in dialysate levels of dopamine and noradrenaline 
      in the medial prefrontal cortex. The increases induced by the four antipsychotic 
      agents in extracellular levels of dopamine and noradrenaline displayed a striking 
      co-variation both in dose and time. A similar co-variation was seen in the 
      decrease of dopamine and noradrenaline, after administration of a low dose (30 
      nmol/kg, s.c.) of the dopamine D2/3 receptor agonist 
      (+)-7-hydroxy-2-(N,N-di-n-propylamino) tetralin ((+)-7-OH-DPAT). It is concluded 
      that there is a close coupling between the release of dopamine and noradrenaline 
      in the medial prefrontal cortex. The mechanism of action of this interaction, 
      that might be of importance for a better understanding of the mechanism of action 
      of antipsychotic drugs, is discussed.
FAU - Westerink, B H
AU  - Westerink BH
AD  - University Center for Pharmacy, Department of Medicinal Chemistry, Groningen, The 
      Netherlands. westerink@farm.rug.nl
FAU - de Boer, P
AU  - de Boer P
FAU - de Vries, J B
AU  - de Vries JB
FAU - Kruse, C G
AU  - Kruse CG
FAU - Long, S K
AU  - Long SK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Piperazines)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 0 (Thiazoles)
RN  - 12794-10-4 (Benzodiazepines)
RN  - 3G0285N20N (Pirenzepine)
RN  - 6UKA5VEJ6X (ziprasidone)
RN  - J60AR2IKIC (Clozapine)
RN  - J6292F8L3D (Haloperidol)
RN  - L6UH7ZF8HC (Risperidone)
RN  - N7U69T4SZR (Olanzapine)
RN  - RR7D75YDF4 (7-hydroxy-2-N,N-dipropylaminotetralin)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*pharmacology
MH  - Benzodiazepines
MH  - Brain/*drug effects/metabolism
MH  - Clozapine/pharmacology
MH  - Dopamine/*metabolism
MH  - Dopamine Agonists/pharmacology
MH  - Extracellular Space/drug effects/metabolism
MH  - Haloperidol/pharmacology
MH  - Male
MH  - Norepinephrine/*metabolism
MH  - Olanzapine
MH  - Piperazines/pharmacology
MH  - Pirenzepine/analogs & derivatives/pharmacology
MH  - Prefrontal Cortex/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reference Values
MH  - Risperidone/pharmacology
MH  - Tetrahydronaphthalenes/pharmacology
MH  - Thiazoles/pharmacology
EDAT- 1998/12/16 00:00
MHDA- 1998/12/16 00:01
CRDT- 1998/12/16 00:00
PHST- 1998/12/16 00:00 [pubmed]
PHST- 1998/12/16 00:01 [medline]
PHST- 1998/12/16 00:00 [entrez]
AID - S0014-2999(98)00711-0 [pii]
AID - 10.1016/s0014-2999(98)00711-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1998 Nov 13;361(1):27-33. doi: 10.1016/s0014-2999(98)00711-0.