PMID- 9852338
OWN - NLM
STAT- MEDLINE
DCOM- 19990322
LR  - 20240322
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 514 ( Pt 2)
IP  - Pt 2
DP  - 1999 Jan 15
TI  - Excitability changes in sacral afferents innervating the urethra, perineum and 
      hindlimb skin of the cat during micturition.
PG  - 593-607
AB  - 1. Excitability changes in afferents innervating the urethra, perineum and 
      hindlimb were measured in decerebrated cats during micturition and in response to 
      stimulation of lumbosacral afferents. Increases in excitability were interpreted 
      as primary afferent depolarization (PAD) and decreases as primary afferent 
      hyperpolarization. 2. Excitability increases were observed in 11 of 19 urethral 
      pudendal afferents during micturition. Four of these 11 afferents showed an 
      excitability increase during voiding. Seven of these showed a biphasic change 
      with a decrease in excitability when sphincter activity resumed at the end of the 
      void. Three of 19 afferents showed an excitability decrease during micturition 
      and no change was detected in five afferents. 3. During micturition, the peak 
      amplitude of urethral afferent-evoked excitatory postsynaptic potentials in seven 
      of eight sphincter motoneurones was diminished to a mean of 36% of control 
      values. 4. Eighty per cent of hindlimb cutaneous afferents and 50% of dorsal 
      penile/clitoral and superficial perineal nerve afferents in the sacral cord 
      showed increased excitability during voiding. No excitability increases were 
      measured in 13 hindlimb cutaneous fibres examined in the lumbar segments. 5. PAD 
      was observed in sacral urethral, perineal and hindlimb cutaneous afferents in 
      response to electrical stimulation of other perineal, urethral, hindlimb 
      cutaneous and group II muscle afferents. 6. It is concluded that control of 
      transmission from urethral afferents by the micturition circuitry is different to 
      that by sensory transmission from hindlimb and perineal regions during 
      micturition. We hypothesize that more than one population of sacral PAD-mediating 
      interneurones is involved.
FAU - Buss, R R
AU  - Buss RR
AD  - Department of Physiology, University of Manitoba, 730 William Avenue, Winnipeg, 
      MB, Canada R3E 3J7.
FAU - Shefchyk, S J
AU  - Shefchyk SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Afferent Pathways/*physiology
MH  - Animals
MH  - Brain Stem/*physiology
MH  - Cats
MH  - Decerebrate State
MH  - Electric Conductivity
MH  - *Excitatory Postsynaptic Potentials
MH  - Female
MH  - Genitalia, Female/innervation
MH  - Hindlimb
MH  - Models, Neurological
MH  - Motor Activity/physiology
MH  - Motor Neurons/*physiology
MH  - Perineum/*innervation
MH  - Skin/*innervation
MH  - Urethra/*innervation
MH  - Urinary Bladder/innervation/*physiology
MH  - Urination/*physiology
PMC - PMC2269077
EDAT- 1998/12/16 00:00
MHDA- 1998/12/16 00:01
PMCR- 2000/01/15
CRDT- 1998/12/16 00:00
PHST- 1998/12/16 00:00 [pubmed]
PHST- 1998/12/16 00:01 [medline]
PHST- 1998/12/16 00:00 [entrez]
PHST- 2000/01/15 00:00 [pmc-release]
AID - 10.1111/j.1469-7793.1999.593ae.x [doi]
PST - ppublish
SO  - J Physiol. 1999 Jan 15;514 ( Pt 2)(Pt 2):593-607. doi: 
      10.1111/j.1469-7793.1999.593ae.x.