PMID- 9854581
OWN - NLM
STAT- MEDLINE
DCOM- 19990111
LR  - 20190915
IS  - 0039-6060 (Print)
IS  - 0039-6060 (Linking)
VI  - 124
IP  - 6
DP  - 1998 Dec
TI  - Pancreatic islet cell tumor metastasis in multiple endocrine neoplasia type 1: 
      correlation with primary tumor size.
PG  - 1043-8, discussion 1048-9
AB  - BACKGROUND: Islet cell tumor (ICT) metastasis is one of the potentially lethal 
      outcomes of multiple endocrine neoplasia type 1 (MEN 1). Management of ICT in 
      patients with MEN 1 is controversial; some advocate resection based on 
      biochemical evidence of progression, whereas others use tumor size to predict the 
      risk of metastasis and the need for resection. This study correlates the size of 
      primary ICT with the presence of metastases. METHODS: Forty-eight patients with 
      MEN 1 with ICT, from 34 kindreds followed up in our multiple endocrine neoplasia 
      program, were evaluated; 43 of the 48 have been explored for ICT. Metastases to 
      the lymph nodes and liver were documented. RESULTS: Thirty-three percent of 
      patients with pancreatic tumors less than 1 cm in greatest diameter had 
      metastatic disease at surgery and in follow-up, whereas 34.8% of patients with 
      tumors greater than 2 cm in diameter had metastases to lymph nodes or liver. The 
      2 patients with liver metastases each had primary tumors greater than 2 cm. 
      Follow-up revealed subsequent metastasis in 1 patient. CONCLUSIONS: The size of 
      primary tumors in MEN 1 does not correlate with metastatic potential. This is not 
      a good criterion for exploration. Continued follow-up of these patients will be 
      necessary to define the effect of operation on the course of ICT in MEN 1.
FAU - Lowney, J K
AU  - Lowney JK
AD  - Department of Surgery, Washington University School of Medicine, St Louis, Mo., 
      USA.
FAU - Frisella, M M
AU  - Frisella MM
FAU - Lairmore, T C
AU  - Lairmore TC
FAU - Doherty, G M
AU  - Doherty GM
LA  - eng
GR  - 5P01-CA53524/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
SB  - IM
MH  - Adenoma, Islet Cell/*pathology
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Liver Neoplasms/*secondary
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*pathology
MH  - Pancreatic Neoplasms/*pathology
MH  - Retrospective Studies
EDAT- 1998/12/17 00:00
MHDA- 1998/12/17 00:01
CRDT- 1998/12/17 00:00
PHST- 1998/12/17 00:00 [pubmed]
PHST- 1998/12/17 00:01 [medline]
PHST- 1998/12/17 00:00 [entrez]
AID - S0039-6060(98)70047-9 [pii]
AID - 10.1067/msy.1998.92561 [doi]
PST - ppublish
SO  - Surgery. 1998 Dec;124(6):1043-8, discussion 1048-9. doi: 10.1067/msy.1998.92561.