PMID- 9855319
OWN - NLM
STAT- MEDLINE
DCOM- 19990210
LR  - 20131121
IS  - 0277-0008 (Print)
IS  - 0277-0008 (Linking)
VI  - 18
IP  - 6
DP  - 1998 Nov-Dec
TI  - In unfractionated heparin dosing, the combination of patient age and estimated 
      plasma volume predicts initial antifactor Xa activity better than patient weight 
      alone.
PG  - 1217-23
AB  - STUDY OBJECTIVE: To determine whether patient factors other than body weight 
      would better predict patients' initial antifactor Xa heparin activity (HA) after 
      start of unfractionated heparin (UFH) therapy. DESIGN: Case series. SETTING: A 
      625-bed, adults-only, private, tertiary care teaching hospital. PATIENTS: 
      Ninety-two patients requiring UFH therapy. INTERVENTIONS: Patients received 
      initial UFH bolus doses of 72-80 U/kg ideal weight and initial UFH infusions of 
      19.1-21.2 U/kg ideal weight. MEASUREMENTS AND MAIN RESULTS: Fifty-five percent of 
      the first 6-hour HA measurements were supratherapeutic (> 0.7 U/ml antifactor Xa 
      activity). Patient weight was inferior to a combination of age and estimated 
      plasma volume in predicting initial HA. A predictive model including these two 
      factors accounted for 38.5% of variation in first HA levels compared with 17.7% 
      with actual weight alone. CONCLUSION: Weight-based UFH dosing may frequently 
      result in nontherapeutic initial HA levels. Initial UFH dosing might be improved 
      if protocols based on patient age and estimated plasma volume were developed.
FAU - Rosborough, T K
AU  - Rosborough TK
AD  - Medical Education Department, Abbott Northwestern Hospital, Minneapolis, 
      Minnesota 55407, USA.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacotherapy
JT  - Pharmacotherapy
JID - 8111305
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/*administration & dosage/pharmacokinetics
MH  - Body Height
MH  - Body Mass Index
MH  - *Body Weight
MH  - Creatinine/blood
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hematocrit
MH  - Heparin/*administration & dosage/blood/pharmacokinetics
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Time Factors
EDAT- 1998/12/17 00:00
MHDA- 1998/12/17 00:01
CRDT- 1998/12/17 00:00
PHST- 1998/12/17 00:00 [pubmed]
PHST- 1998/12/17 00:01 [medline]
PHST- 1998/12/17 00:00 [entrez]
PST - ppublish
SO  - Pharmacotherapy. 1998 Nov-Dec;18(6):1217-23.