PMID- 9857269
OWN - NLM
STAT- MEDLINE
DCOM- 19990305
LR  - 20161124
IS  - 0300-9831 (Print)
IS  - 0300-9831 (Linking)
VI  - 68
IP  - 6
DP  - 1998
TI  - Metabolism of retinoic acid: implications for development and cancer.
PG  - 404-10
AB  - Vitamin A derived retinoids, including all-trans retinoic acid (RA), play an 
      important role in regulating cellular growth and differentiation. Biological 
      activities of retinoids are mediated through interactions with two classes of 
      nuclear receptors, RA receptors (RARs) and retinoid X receptors (RXRs). In 
      addition, cellular retinoid-binding proteins (CRBPs and CRABPs) and 
      RA-metabolizing enzymes may explain the pleiotropic effects of retinoids. 
      Recently, a novel cytochrome P450 enzyme (CYP26) with specific RA 4-hydroxylase 
      activity, which is rapidly induced by RA, has been cloned from man, mouse and 
      zebra fish, fullfilling all requirements of an enzyme which could be of crucial 
      importance in controlling steady-state levels of active retinoids in cells and 
      target tissues, thus protecting against excessive exposure. Besides the putative 
      role of this newly identified CYP26 in contributing to susceptibility of cancer 
      cells to retinoids, the possible function of this gene in early embryonic 
      development is discussed.
FAU - Sonneveld, E
AU  - Sonneveld E
AD  - Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, 
      Netherlands.
FAU - van der Saag, P T
AU  - van der Saag PT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Int J Vitam Nutr Res
JT  - International journal for vitamin and nutrition research. Internationale 
      Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de 
      vitaminologie et de nutrition
JID - 1273304
RN  - 0 (Receptors, Retinoic Acid)
RN  - 5688UTC01R (Tretinoin)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - EC 1.14.14.1 (Retinoic Acid 4-Hydroxylase)
SB  - IM
MH  - Animals
MH  - Cytochrome P-450 Enzyme System/physiology
MH  - *Embryonic and Fetal Development
MH  - Humans
MH  - Neoplasms/*prevention & control
MH  - Receptors, Retinoic Acid/physiology
MH  - Retinoic Acid 4-Hydroxylase
MH  - Tretinoin/*metabolism
RF  - 47
EDAT- 1998/12/19 00:00
MHDA- 1998/12/19 00:01
CRDT- 1998/12/19 00:00
PHST- 1998/12/19 00:00 [pubmed]
PHST- 1998/12/19 00:01 [medline]
PHST- 1998/12/19 00:00 [entrez]
PST - ppublish
SO  - Int J Vitam Nutr Res. 1998;68(6):404-10.